Frontiers of Optoelectronics, 2016, 9 (2): 206, 网络出版: 2016-10-21
Review of design principles of 2D photonic crystal microcavity biosensors in silicon and their applications
Review of design principles of 2D photonic crystal microcavity biosensors in silicon and their applications
photonic crystal (PC) sensor photonic crystal (PC) sensor biosensor biosensor slowlight slowlight photonic crystal microcavity (PCM) photonic crystal microcavity (PCM) photonic crystal waveguide (PCW) photonic crystal waveguide (PCW) high sensitivity high sensitivity high specificity high specificity photonic integrated circuits (PICs) photonic integrated circuits (PICs) nanophotonics nanophotonics
摘要
In this paper, we reviewed the design principles of two-dimensional (2D) silicon photonic crystal microcavity (PCM) biosensors coupled to photonic crystal waveguides (PCWs). Microcavity radiation loss is controlled by engineered the cavity mode volume. Coupling loss into the waveguide is controlled by adjusting the position of the microcavity from the waveguide. We also investigated the dependence of analyte overlap integral (also called fill fraction) of the resonant mode as well as the effect of group index of the coupling waveguide at the resonant wavelength of the microcavity. In addition to the cavity properties, absorbance of the sensing medium or analyte together with the affinity constant of the probe and target biomarkers involved in the biochemical reaction also limits the minimum detection limits. We summarized our results in applications in cancer biomarker detection, heavy metal sensing and therapeutic drug monitoring.
Abstract
In this paper, we reviewed the design principles of two-dimensional (2D) silicon photonic crystal microcavity (PCM) biosensors coupled to photonic crystal waveguides (PCWs). Microcavity radiation loss is controlled by engineered the cavity mode volume. Coupling loss into the waveguide is controlled by adjusting the position of the microcavity from the waveguide. We also investigated the dependence of analyte overlap integral (also called fill fraction) of the resonant mode as well as the effect of group index of the coupling waveguide at the resonant wavelength of the microcavity. In addition to the cavity properties, absorbance of the sensing medium or analyte together with the affinity constant of the probe and target biomarkers involved in the biochemical reaction also limits the minimum detection limits. We summarized our results in applications in cancer biomarker detection, heavy metal sensing and therapeutic drug monitoring.
Swapnajit CHAKRAVARTY, Xiangning CHEN, Naimei TANG, Wei-Cheng LAI, Yi ZOU, Hai YAN, Ray T. CHEN. Review of design principles of 2D photonic crystal microcavity biosensors in silicon and their applications[J]. Frontiers of Optoelectronics, 2016, 9(2): 206. Swapnajit CHAKRAVARTY, Xiangning CHEN, Naimei TANG, Wei-Cheng LAI, Yi ZOU, Hai YAN, Ray T. CHEN. Review of design principles of 2D photonic crystal microcavity biosensors in silicon and their applications[J]. Frontiers of Optoelectronics, 2016, 9(2): 206.