针对中药炮制前后成分变化会影响中药用药疗效的问题, 采用四种大黄炮制品为研究对象, 利用太赫兹时域光谱系统和化学计量学处理方法获得了中药大黄光谱数据, 按照中药大黄炮制品的种类对光谱数据进行了区分。 同时, 薄层色谱法研究显示大黄在不同炮制方法处理后, 其炮制品中基础物质蒽醌和鞣质类化合物含量发生变化, 而该实验获得的这四种大黄炮制品太赫兹光谱数据之间的关联性与上述变化规律相吻合。 这就说明太赫兹光谱技术对中药炮制品的物质成分是敏感的, 此方法可以为中药炮制过程中物质结构变化的研究提供重要参考。

The changes of composition of the processed traditional Chinese medicine will affect the curative effect of drug, such as the four kinds of processed rhubarb. The characteristics data of each rhubarb was measured with terahertz spectroscopy system and analyzed with chemometrics, and the spectral data was classified according to the category of rhubarb. The substance components of anthraquinone and tannins make changes in processed rhubarb by thin layer chromatography (TLC). The correlation among the terahertz spectroscopy of processed rhubarb was in accordance with the variations of content. This means that terahertz spectroscopy is sensitive to the substance components of processed Chinese traditional medicine. It can also pave the way for the study of the structural changes of traditional Chinese medicine.