肿瘤标志物在人类医学及恶性肿瘤的早期诊断、治疗监测及预后评估方面具有重要作用。目前血清肿瘤标志物的检测方法主要有放射免疫法(RIA)，酶联免疫吸附法(ELISA)及化学发光免疫法(CLEIA)等，这些方法各自存在放射性污染、操作繁琐、检测时间长、价格昂贵等缺点，限制了血清肿瘤标志物在临床医学及肿瘤检测中的应用。新近出现的基于局域表面等离子体共振效应(LSPR)的传感器因在生物医学检测领域极具优势而成为研究热点。基于局域表面等离子体共振效应的生物传感器，利用贵金属纳米结构对周围介质环境变化敏感的基本原理，可将生物分子吸附引发的金属纳米颗粒外界介质折射率的改变转化为可测量的LSPR峰值吸收波长有规律的移动以实现对传感器表面样品的检测，具备检测灵敏度高、特异性好、免标记、设备便携、成本低的优点，具备临床检测潜力。但到目前为止，利用此传感器检测与疾病及肿瘤相关的肿瘤标志物的类似研究报道较少。在本文中，我们针对LSPR生物传感器的传感原理、国内外的研究进展以及我们在此方面的主要研究成果进行了综述。

Tumor biomarker plays an important role in early diagnosis, treatment evaluation, and prognosis pre-diction for human medicine and cancers. At present, the human serum tumor biomarker detection methods mainly include radioimmunoassay (RIA), enzyme linked immunosorbent assay (ELISA), and chemilumines-cence immunoassay (CLEIA), which have disadvantages of radioactive contamination, complicated operation, and long detection time and high cost. Various issues exist in these methods which limit its widespread applica-tions in clinic screening. Recently, biosensors based on localized surface plasmon resonance (LSPR) have at-tracted much research attention for their remarkable superiority in the domain of biomedicine detection. The LSPR biosensor, a novel type of optical fiber-based biosensor, uses an optical fiber or optical fiber bundle to transform biological recognition information into analytically useful signals in the LSPR spectrum, which is suita-ble for clinical detection because of the advantages of high sensitivity, high specificity, label free, portable equipment and lower cost. However, up to now, there was little progress on the report of the detection of tumor biomarkers associated diseases and tumors by using this LSPR biosensor. In this paper, the principle and re-search progress of local surface plasmon resonance biosensor, as well as the main findings of our study in the detection of tumor markers are reviewed.