Chinese Optics Letters, 2017, 15 (8): 083001, Published Online: Jul. 20, 2018  

Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system Download: 1462次

Author Affiliations
1 State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Science (CAS), Xi’an 710119, China
2 University of Chinese Academy of Sciences (CAS), Beijing 100049, China
3 State Key Laboratory of Power Systems, Department of Thermal Engineering, Tsinghua-BP Clean Energy Center, Tsinghua University, Beijing 100084, China
4 School of Science, Xi’an Jiaotong University, Xi’an 710049, China
Abstract
In this Letter, a miniature wearable Raman spectroscopy system is developed. A wearable fiber-optic probe is employed to help the stable and convenient collection of Raman spectra. A nonlinear partial least squares model based on a multivariate dominant factor is employed to predict the glucose level. The mean coefficients of determination are 0.99, 0.893, and 0.844 for the glucose solution, laboratory rats, and human volunteers. The results demonstrate that a miniature wearable Raman spectroscopy system is feasible to achieve the noninvasive detection of human blood glucose and has important clinical application value in disease diagnosis.

Yi Zheng, Xiangping Zhu, Zhe Wang, Zongyu Hou, Fei Gao, Rongzhi Nie, Xiaoxia Cui, Jiangbo She, Bo Peng. Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system[J]. Chinese Optics Letters, 2017, 15(8): 083001.

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