首页 > 论文 > 激光与光电子学进展 > 54卷 > 8期(pp:83004--1)

基于可调谐半导体激光吸收光谱技术的西林瓶检漏方法

Leakage Detection of Vial Based on Tunable Diode Laser Absorption Spectroscopy

  • 摘要
  • 论文信息
  • 参考文献
  • 被引情况
  • PDF全文
分享:

摘要

冻干制品灌装过程极易使西林瓶出现裂纹, 裂纹及塞子与瓶口装配不紧等都会导致空气进入西林瓶内, 使瓶内的药品变质或变性。基于可调谐半导体激光吸收光谱(TDLAS)技术建立了西林瓶检漏测量系统, 该系统可对西林瓶的密封性实现快速无干扰检测。通过分析参考光路与探测光路中水蒸气的物质的量分数差Δx与参考光路中水蒸气的物质的量分数xr之间的关系, 得到了不同湿度环境下的检测阈值。首先对该系统的测量精度进行了验证, 结果表明测量标准误差小于0.007%;然后在xr分别为1.29%、1.33%、1.89%、2.20%时, 对10个西林瓶进行检测, 4号和8号西林瓶在不同xr下的Δx均大于对应的阈值, 判定为泄漏瓶, 与实际泄漏情况相吻合。

Abstract

The vials easily crack in the filling process of freeze-dried products. Cracks and loose assembly of the vial plugs causes air to enter the vials, and thus leads to the metamorphism or degeneration of the freeze-dried products. A measurement system based on tunable diode laser absorption spectroscopy (TDLAS) was developed for fast and non-invasive leakage detection of vials. By analyzing the mole fraction difference of water vapor between the detection light path and the reference light path (Δx) and mole fraction of water vapor (xr) of the reference light path, the threshold at different conditions is obtained. The measurement accuracy of the system is validated firstly, and it reveals that the standard deviation of the system is less than 0.007%. Then, ten vials are detected when xr is 1.29%, 1.33%, 1.89%, 2.20%, respectively. Vials No.4 and No.8 are considered as leaked vials, since Δx is larger than the corresponding threshold at various mole fractions of water vapor xr, and the results are in good agreement with the real situation.

投稿润色
补充资料

中图分类号:TK31

DOI:10.3788/lop54.083004

所属栏目:光谱学

基金项目:国家自然科学基金(51676130, 51306123)、博士点基金联合资助课题新教师类(20133120120008)、上海市科委科研计划(13DZ2260900)

收稿日期:2017-02-28

修改稿日期:2017-04-14

网络出版日期:--

作者单位    点击查看

王明明:上海理工大学能源与动力工程学院, 上海 200093
戴伟国:上海笙港光学科技有限公司, 上海 200093
杨荟楠:上海理工大学能源与动力工程学院, 上海 200093
陈军:上海理工大学能源与动力工程学院, 上海 200093
苏明旭:上海理工大学能源与动力工程学院, 上海 200093
蔡小舒:上海理工大学能源与动力工程学院, 上海 200093

联系人作者:王明明(18116473146@163.com)

备注:王明明(1991-), 男, 硕士研究生, 主要从事TDLAS技术测量方面的研究。

【1】Shi Weiqin, Lou Wei. The domestic medical lyophilizer development nearly fifteen years and trend expectation[J]. Drying Technology & Equipment, 2011, 9(1): 3-8.
史伟勤, 楼 唯. 国产真空冷冻干燥机近十五年来的进展与趋势展望[J]. 干燥技术与设备, 2011, 9(1): 3-8.

【2】Liu Ping. Systems of vials automatic loading and unloading from freeze-dryer[J]. Technological Development of Enterprise, 2011, 30(9): 5-7.
刘 平. 西林瓶自动进出冻干机系统[J]. 企业技术开发, 2011, 30(9): 5-7.

【3】Miao Xianhua. Study of schering bottles measurement technology[J]. Modern Manufacturing Technology and Equipment, 2015(5): 49-51.
苗现华. 西林瓶的测量工艺研究[J]. 现代制造技术与装备, 2015(5): 49-51.

【4】Barresi A A, Pisano R, Fissore D, et al. Monitoring of the primary drying of a lyophilization process in vials[J]. Chemical Engineering & Processing, 2009, 48: 408-423.

【5】Yang Zongfang, Bai Jianyu. Vial size detection based on machine vision[J]. Computer Measurement & Control, 2016, 24(8): 63-66.
杨宗芳, 白剑宇. 基于机器视觉的西林瓶尺寸检测[J]. 计算机测量与控制, 2016, 24(8): 63-66.

【6】Zhang Hanle, Mao Jianxu, Zhang Xiaolin. Research on automatic visual inspection method and system for defects of vials[J]. Computer Engineering and Applications, 2014, 50(19): 147-151.
张寒乐, 毛建旭, 张晓琳. 西林瓶缺陷自动视觉检测方法与系统研究[J]. 计算机工程与应用, 2014, 50(19): 147-151.

【7】Yu Peiming, Huang Taikang. Discussion on treatment of deteriorated and contaminated drugs[J]. Chinese Pharmaceutical Affairs, 2007, 21(3): 160-161.
于培明, 黄泰康. 变质或被污染药品的法律处理探讨[J]. 中国药事, 2007, 21(3): 160-161.

【8】Dolan S A, Felizardo G, Barnes S, et al. APIC position paper: safe injection, infusion, and medication vial practices in health care[J]. American Journal of Infection Control, 2016, 44: 750-757.

【9】Vertucci F J, Beatty R G. Apical leakage associated with retrofilling techniques:a dye study[J]. Journal of Endodontics, 1986, 12(8): 331-336.

【10】Sivaramakrishna V, Raspante F, Palaniappan S, et al. PET bottles seal quality testing using an on-line pressure differential detector[J]. Journal of Food Engineering, 2007, 80: 645-654.

【11】Fan Yue. Inspection for leakage of vials[J]. Heilongjiang Medicine Journal, 2014, 27(3): 593-595.
樊 玥. 西林瓶容器气密性检查[J]. 黑龙江医药, 2014, 27(3): 593-595.

【12】Yang H, Greszik D, Dreier T, et al. Simultaneous measurement of liquid water film thickness and vapor temperature using near-infrared tunable diode laser spectroscopy[J]. Applied Physics B, 2010, 99: 385-390.

【13】Barbu T L, Vinogradov I, Durry G, et al. TDLAS a laser diode sensor for the in situ monitoring of H2O, CO2, and their isotopes in the Martian atmosphere[J]. Advances in Space Research, 2006, 38: 718-725.

【14】Chen Jiuying, Liu Jianguo, He Junfeng, et al. Study of high temperature water vapor concentration measurement method based on absorption spectroscopy[J]. Spectroscopy and Spectral Analysis, 2014, 34(12): 3174-3177.
陈玖英, 刘建国, 何俊峰, 等. 基于吸收光谱原理的高温水汽浓度测量方法研究[J]. 光谱学与光谱分析, 2014, 34(12): 3174-3177.

【15】Jia Liangquan, Liu Wenqing, Kan Ruifeng, et al. Study on oxygen velocity measurement in wind tunnel by wavelength modulation-TDLAS technology[J]. Chinese J Lasers, 2015, 42(7): 0715001.
贾良权, 刘文清, 阚瑞峰, 等. 波长调制-TDLAS技术测量风洞中氧气流速方法研究[J]. 中国激光, 2015, 42(7): 0715001.

【16】Wang Yan, Zhang Rui. Photo detector characteristics effect on TDLAS gas detection[J]. Acta Optica Sinica, 2016, 36(2): 0230002.
王 燕, 张 锐. 光电探测器特性在TDLAS气体检测中的影响[J]. 光学学报, 2016, 36(2): 0230002.

【17】Yang Huinan, Guo Xiaolong, Su Mingxu, et al. Liquid-water film-thickness online measurement in a flow channel by TDLAS[J]. Chinese J Lasers, 2014, 41(12): 1208010.
杨荟楠, 郭晓龙, 苏明旭, 等. 基于TDLAS技术在线测量气流道内液膜动态厚度[J]. 中国激光, 2014, 41(12): 1208010.

【18】Xia Hui, Liu Wenqing, Zhang Yujun, et al. Experimental design of H2O concentration measurement with tunable diode laser spectroscopy in combustion environment[J]. Journal of Atmospheric and Environmental Optics, 2007, 2(3): 214-217.
夏 慧, 刘文清, 张玉钧, 等. 可调谐二极管激光光谱技术测量燃烧环境下H2O浓度的实验设计[J]. 大气与环境光学学报, 2007, 2(3): 214-217.

【19】Li Fei, Yu Xilong, Chen Lihong, et al. Temperature and water vapour concentration measurements of CH4/air premixed flat flame based on TDLAS[J]. Journal of Experiments in Fluid Mechanics, 2009, 23(2): 40-44.
李 飞, 余西龙, 陈立红, 等. TDLAS测量甲烷/空气预混平面火焰温度和H2O浓度[J]. 实验流体力学, 2009, 23(2): 40-44.

【20】He Ying, Zhang Yujun, Wang Liming, et al. Study on large-scale regional laser detection methods for water vapor concentration[J]. Spectroscopy and Spectral Analysis, 2013, 33(3): 608-612.
何 莹, 张玉钧, 王立明, 等. 大尺度区域水汽浓度激光检测方法的研究[J]. 光谱学与光谱分析, 2013, 33(3): 608-612.

【21】Yang H, Guo X, Su M, et al. Novel method for simultaneous measurement of film thickness and mass fraction of urea-water solution[J]. Chinese Optics Letters, 2014, 12(12): 123102.

【22】Yang H, Guo X, Zhou W, et al. Investigation on liquid film of urea-water solutions with diode laser absorption spectroscopy[J]. Experiments in Fluids, 2015, 56: 73.

【23】Mo Xiaobao, Xiang Liu, Huang Zhi, et al. Study on evaporation from a free water surface using laser absorption spectroscopy[J]. Chinese J Lasers, 2015, 42(10): 1015003.
莫小宝, 向 柳, 黄 志, 等. 基于激光吸收光谱法的自由水面蒸发研究[J]. 中国激光, 2015, 42(10): 1015003.

引用该论文

Wang Mingming,Dai Weiguo,Yang Huinan,Chen Jun,Su Mingxu,Cai Xiaoshu. Leakage Detection of Vial Based on Tunable Diode Laser Absorption Spectroscopy[J]. Laser & Optoelectronics Progress, 2017, 54(8): 083004

王明明,戴伟国,杨荟楠,陈军,苏明旭,蔡小舒. 基于可调谐半导体激光吸收光谱技术的西林瓶检漏方法[J]. 激光与光电子学进展, 2017, 54(8): 083004

您的浏览器不支持PDF插件,请使用最新的(Chrome/Fire Fox等)浏览器.或者您还可以点击此处下载该论文PDF