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生物组织的亚扩散散射及其光谱技术的应用

Sub-Diffuse Scattering of Biological Tissues and Its Application to Spectroscopy

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摘要

采用Monte Carlo模拟研究了单光纤反射探针的漫反射率, 发现小孔径探测器收集到的亚扩散光对散射相函数是敏感的, 而散射相函数与生物组织的微观结构有关。研究了一个适用于小孔径测量的半经验漫反射模型, 分析了与生物组织微观结构有关的二阶和三阶光学参量对该模型的影响。结果表明, 两个高阶光学参量对漫反射的影响具有相反的效果, 并且对于光学各向异性的生物组织, 这两种影响是不可忽略的。给出了一个简化的半经验模型及其适用条件, 这为生物组织散射特性及相关微观结构的在体测量提供了新的技术支持。

Abstract

The diffuse reflectance of single-fiber reflectance probe is studied with the Monte Carlo simulation, and we find that the sub-diffuse scattering light is sensitive to the scattering phase function (SPF) related to tissue microstructure. A semi-empirical diffuse reflection model for small aperture measurement is studied, and the influences of second-order and third-order optic parameters on this model are analyzed. It shows that the two parameters have contrary effects on diffuse reflectance, and both effects are non-negligible for optically anisotropic biological tissues. A simplified semi-empirical model and its application condition are given, which provides potentially applicable support for measurement of tissue scattering properties and associated microstructure.

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中图分类号:O439

DOI:10.3788/cjl201744.0807001

所属栏目:生物医学光子学与激光医学

基金项目:国家自然科学基金(60278004)

收稿日期:2017-02-23

修改稿日期:2017-03-31

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刘 迎:天津大学理学院光电信息技术教育部重点实验室, 天津 300072
罗雯倩:天津大学理学院光电信息技术教育部重点实验室, 天津 300072
王汝丹:天津大学理学院光电信息技术教育部重点实验室, 天津 300072
王 兴:天津大学理学院光电信息技术教育部重点实验室, 天津 300072

联系人作者:刘迎(liuying56@163.com)

备注:刘 迎(1956-), 男, 教授, 博士生导师, 主要从事生物医学光子学及集成光电子学等方面的研究。

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引用该论文

Liu Ying,Luo Wenqian,Wang Rudan,Wang Xing. Sub-Diffuse Scattering of Biological Tissues and Its Application to Spectroscopy[J]. Chinese Journal of Lasers, 2017, 44(8): 0807001

刘 迎,罗雯倩,王汝丹,王 兴. 生物组织的亚扩散散射及其光谱技术的应用[J]. 中国激光, 2017, 44(8): 0807001

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