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A fluorescent porous silicon-based biosensor for small molecule detection

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Abstract

Fluorescent porous silicon was prepared as a stable biosensor chip substrate. The aminopropyltriethoxysilane (APTES) molecules are attached in the pores of the porous silicon with a crosslink method, and when the molecules are added into the chip, the fluorescence intensity is reduced according to the concentration of the APTES. Controlled experiments are also presented with the small molecule that cannot be covalently coupled, and the results show that this kind of sensor chip has better specificity. Compared with other conventional methods, this method is simple, quick and label- free.

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DOI:10.1007/s11801-016-6182-3

基金项目:This work has been supported by the National Natural Science Foundation of China (Nos.11264038 and 62165009), the Doctor Startup Project of Xinjiang University (No.BS120122), and the Reserve Talents Project of National High-level Personnel of Special Support Program (2014). Lü Guo-dong and Lü Xiao-yi contributed equally to this work.

收稿日期:2016-08-22

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Lü Xiao-yi:School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China
Lü Guo-dong:Xinjiang Key Laboratory of Echinococcosis, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China
MO Jia-qing:School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China
XU Liang:School of Electrical Engineering, Tianjin University of Technology, Tianjin 300384, China
JIA Zhen-hong:School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China

联系人作者:JIA Zhen-hong(jzhh@xju.edu.cn)

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引用该论文

Lü Xiao-yi,Lü Guo-dong,MO Jia-qing,XU Liang,JIA Zhen-hong. A fluorescent porous silicon-based biosensor for small molecule detection[J]. 光电子快报(英文版), 2016, 12(6): 478-480

Lü Xiao-yi,Lü Guo-dong,MO Jia-qing,XU Liang,JIA Zhen-hong. A fluorescent porous silicon-based biosensor for small molecule detection[J]. Optoelectronics Letters, 2016, 12(6): 478-480

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