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光声显微成像技术研究进展及其应用

Progress and Application of Photoacoustic Microscopy Technique

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摘要

光声显微成像技术是近年发展迅速的一种基于光学吸收差异的成像技术,它继承了光学成像对比度高、超声成像深度深的优点,表现出纯光学显微成像技术所无法比拟的优越性。光声显微成像实现了从声学分辨率至光学分辨率的多尺度成像,发展出从单纯的吸收结构到功能的多参量成像、从依靠内源吸收体到外源对比剂的多对比度成像、从依赖超声换能器到全光学激发与探测、从单一吸收成像到与光学相干层析成像、荧光成像、双光子成像、二次谐波成像等结合形成多模态的光声显微成像技术。现已在血管生物学、肿瘤学、神经学、眼科学,以及皮肤学等生物医学领域得到应用。

Abstract

Photoacoustic microscopy is a fast-developing imaging technology, which depends on the optical absorption differences and inherits high contrast of optical imaging and deeper depth of ultrasound imaging. Thus, photoacoustic microscopy presents more merit than optical microscopy. Photoacoustic microscopy realizes multiscale imaging from acoustical resolution to the optical resolution, which provides multi-parameters imaging from simple absorption structure to its function, multi-contrast imaging from endogenous contrast agents to exogenous contrast agent, and imaging from ultrasound-transducer-based to all-optical excitation and detection, and multimodality imaging combined with optical coherence tomography, fluorescence imaging, two-photon imaging, second harmonic imaging, etc. Photoacoustic microscopy is widely applied in the field of biomedicine, such as vascular biology, oncology, neurology, ophthalmology, dermatology, and so on.

Newport宣传-MKS新实验室计划
补充资料

中图分类号:Q631

DOI:10.3788/cjl201845.0307008

所属栏目:“生物医学光子学新技术及进展”专题

基金项目:国家自然科学基金(61705068,61627827,61331001,81630046,91539127)、广东省自然科学基金(2015B020233016,2014B020215003,2014A020215031,2017A030310363)、广东省“特支计划”科技青年拔尖人才(2015TQ01X882)、广东省高等学校优秀青年教师培养计划(YQ2015049)

收稿日期:2017-09-15

修改稿日期:2017-11-02

网络出版日期:--

作者单位    点击查看

陈重江:华南师范大学生物光子学研究院激光生命科学研究所暨激光生命科学教育部重点实验室, 广东 广州 510631
杨思华:华南师范大学生物光子学研究院激光生命科学研究所暨激光生命科学教育部重点实验室, 广东 广州 510631
邢达:华南师范大学生物光子学研究院激光生命科学研究所暨激光生命科学教育部重点实验室, 广东 广州 510631

联系人作者:杨思华(yangsh@scnu.edu.cn)

备注:陈重江(1987-),男,博士,讲师,主要从事光声成像技术及其应用方面的研究。E-mail: chenchj@scnu.edu.cn

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引用该论文

Chen Zhongjiang,Yang Sihua,Xing Da. Progress and Application of Photoacoustic Microscopy Technique[J]. Chinese Journal of Lasers, 2018, 45(3): 0307008

陈重江,杨思华,邢达. 光声显微成像技术研究进展及其应用[J]. 中国激光, 2018, 45(3): 0307008

被引情况

【1】乔伟,陈重江. 基于光学相干检测的非接触式光声多普勒流速仪. 激光生物学报, 2018, 27(4): 338-344

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