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静脉腔内激光治疗的蒙特卡罗模拟

Monte Carlo Simulation of Endovenous Laser Treatment

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摘要

静脉腔内激光治疗已成为治疗静脉曲张最有前途的技术之一, 了解激光在血管及其周围组织中的传输, 有助于选择合适的治疗参数, 可以在关闭静脉的同时避免并发症;依据静脉及其周围组织的结构特征, 构建三维管状结构的光学模型, 利用三维蒙特卡罗算法研究了不同波长激光辐照下的光分布特性, 探讨了血管管径、辐照位置、光学特性参数对治疗效果的影响。结果表明: 波长的选择需要考虑治疗血管的直径, 1500 nm激光对静脉周围组织的损伤较小, 但光能流率衰减较快, 适合治疗较细的血管;1320 nm激光的光能流率衰减较慢, 适合治疗较粗的血管;在治疗过程中, 光源应尽量保持在中轴线上, 以避免血管壁发生溃疡和穿孔;减小血液的吸收系数和散射系数, 更容易对静脉周围组织造成损伤;提出的模拟方法有助于静脉激光治疗临床医用中治疗方案的优化设计。

Abstract

Endovenous laser treatment is one of the most promising techniques for treating varicosity. We can select the proper treatment parameters, and avoid complications at the time of closing veins, after understanding the transmission of laser in vessels and perivenous tissues. Based on structure features of veins and perivenous tissues, an optical model of 3D tubular structure is established. The 3D Monte carlo algorithm is used to study the distribution of light with different wavelengths and discuss the influences of vessel thickness, irradiation site, and optical parameters on treatment curative effect. The results show that the selection of wavelength should consider the diameter of vessels. The laser with wavelength of 1500 nm has a small injury on perivenous tissues of veins, but the fluence attenuation is relatively quick, so it is available for treating thin vessels. The fluence attenuation of 1320 nm laser is relatively slow, so it is available for treating thick vessels. During the treatment process, the light source should be kept in the central axis, avoiding ulceration and perforation of vessel wall. It is likely to damage the tissues around the vein through reducing absorption coefficient and scattering coefficient in blood. The proposed simulation method may be helpful to the optimization and design of vein laser treatment in clinical medicine treatment plan.

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中图分类号:R318.51

DOI:10.3788/lop55.021701

所属栏目:医用光学与生物技术

基金项目:福建省教育厅中青年教师教育科研项目(科技A类)(JA11205, JAT170516)、莆田市科技计划(2016G2006)、福建省激光精密加工工程技术研究中心开放式基金(20150504)

收稿日期:2017-08-08

修改稿日期:2017-09-11

网络出版日期:--

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肖郑颖:莆田学院工程实训中心, 福建 莆田 351100

联系人作者:肖郑颖(xiaozhengy0@163.com)

备注:肖郑颖(1985—), 女, 硕士, 实验师, 主要从事生物医学光子学方面的研究。 E-mail:

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引用该论文

Xiao Zhengying. Monte Carlo Simulation of Endovenous Laser Treatment[J]. Laser & Optoelectronics Progress, 2018, 55(2): 021701

肖郑颖. 静脉腔内激光治疗的蒙特卡罗模拟[J]. 激光与光电子学进展, 2018, 55(2): 021701

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