Chinese Optics Letters, 2018, 16 (3): 031702, Published Online: Jul. 13, 2018  

Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment Download: 705次

Author Affiliations
1 Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China
2 MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
3 Department of Cardiology, The Juye Hospital of Traditional Chinese Medicine, Heze 274900, China
Abstract
Photoacoustic imaging (PAI) has been used to characterize the spatial and quantitative features of lipid-rich atherosclerotic plaques with high sensitivity and specificity. In this Letter, we first validate that the ultra-low temperature and formaldehyde treatment have no effect on photoacoustic characteristics of the artery samples. Comparative experiments between the PAI and histological results demonstrate that the ultra-low temperature or formaldehyde treatment has few effects on the PAI of the lipid-rich atherosclerotic plaques; the lipid relative concentration and the lipid percentage by PAI hold high correlation with histology.

Mingjun Xu, Peng Lei, Jianqin Feng, Fangfang Liu, Sihua Yang, Pengfei Zhang. Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment[J]. Chinese Optics Letters, 2018, 16(3): 031702.

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