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Boundary Region of Stomach Mucinous Carcinoma with Swept Source Optical Coherence Tomography

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To provide a real-time intraoperative feedback and suggest an applied potential to guide stomach cancer surgery for removal of normal tissue as little as possible, we use an optical coherence tomography (OCT) to image normal tissue and tumor tissue of 39 stomach cancerous patients, and compare OCT images and pathological sections. The results show that OCT images of 38 patients show obvious difference between normal tissue and tumor tissue. For the 4 stomach mucinous carcinomas, the mucus secreted by tumor of stomach mucinous carcinoma destroys the layer structure, texture, and mucosa of stomach tissue. The poorer backscattering of mucus and the greater difference between backscattering of mucosal tissue make the OCT images of stomach mucinous carcinoma clearer. The B-mode ultrasonic scanning (B-scan) OCT images can distinguish the boundary of the cancerous tissue and the normal tissue. A volumetric image can be built with B-scan images by the three-dimensional (3D) reconstruction method. The layered section images in tissue-depth direction are obtained after volumetric surface flattening. These images provide another dimensionality to view stomach cancerous boundary. The cross validation with B-scan images can show excellent distinction.









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罗斯特:清华大学电子工程系, 北京 100084
范应威:清华大学生物医学工程系, 北京 100084
常玮:清华大学生物医学工程系, 北京 100084
安昕:中国科学院苏州纳米技术与纳米仿生研究所, 江苏 苏州 215123佛山市欧谱曼迪科技有限公司, 广东 佛山 528000
赵辉:佛山市欧谱曼迪科技有限公司, 广东 佛山 528000
霍力:清华大学电子工程系, 北京 100084


备注:罗斯特(1987-),男,博士研究生,主要从事生物光子学、医学成像方面的研究。E-mail: lost147258@163.com

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Luo Site,Fan Yingwei,Chang Wei,An Xin,Zhao Hui,Huo Li. Boundary Region of Stomach Mucinous Carcinoma with Swept Source Optical Coherence Tomography[J]. Acta Optica Sinica, 2018, 38(5): 0517001

罗斯特,范应威,常玮,安昕,赵辉,霍力. 扫频光学相干层析成像应用于判断黏液型胃癌边界区域[J]. 光学学报, 2018, 38(5): 0517001

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