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基于太赫兹光谱的固体片剂孔隙率研究

Porosity of Tablets Based on Terahertz Spectroscopy

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摘要

内部孔隙影响着药片的崩解特性,进而影响药效的发挥,但目前鲜有关于药片孔隙率有效检测手段的报道。基于太赫兹脉冲的飞行时间测量原理,利用太赫兹时域光谱技术研究了微晶纤维素和吲哚美辛混合片剂的孔隙率与折射率、吲哚美辛质量分数之间的定量关系;建立了三者关系的数学计算模型,通过实际测试固体样品片剂的太赫兹时域光谱,计算了片剂的孔隙率、折射率。结果表明:片剂的孔隙率与折射率、不同成分质量分数间存在线性关系,与建立的数学计算模型相符。利用太赫兹光谱法测得的孔隙率与采用气体置换法测量的孔隙率的平均相对误差为6.0%,与采用密度法计算的孔隙率的平均相对误差为8.9%,表明利用太赫兹光谱法测量片剂孔隙率具有可行性,能够成为药物片剂质量监测的补充手段。

Abstract

The inner porosity of tablets plays an important role in its disintegration characteristics, and then affects its efficacy. However, few researches have been reported to detect tablets porosity so far. The quantitative relationship between the porosity, refractive index and the indomethacin mass fraction of mixed tablets composed by microcrystalline cellulose (MCC) and indomethacin (API) is studied using terahertz spectroscopy based on the time delay effect of terahertz pulse, and its mathematical model is built. The porosity and reflective index are calculated by measuring terahertz spectrum of the tablets. The results show that the relationship between porosity and reflective index or mass fractions of different compositions is a linear correlation, which is consistent with the mathematical model. The average relative error of porosity obtained by terahertz spectroscopy and gas replacement method is 6.0%, and the average relative error of porosity obtained by terahertz spectroscopy and density method is 8.9%. The terahertz spectroscopy can be used to measure the porosity of the tablet, and it is a supplementary measure in monitoring the quality of the tablets.

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中图分类号:O433.4

DOI:10.3788/aos201838.0630001

所属栏目:光谱学

基金项目:国家自然科学基金(61675151)

收稿日期:2017-12-26

修改稿日期:2018-01-19

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作者单位    点击查看

赖慧彬:天津大学精密测试技术及仪器国家重点实验室, 天津 300072天津大学太赫兹研究中心, 天津 300072
何明霞:天津大学精密测试技术及仪器国家重点实验室, 天津 300072天津大学太赫兹研究中心, 天津 300072
田甜:天津大学精密测试技术及仪器国家重点实验室, 天津 300072天津大学太赫兹研究中心, 天津 300072
孙珑玲:天津大学精密测试技术及仪器国家重点实验室, 天津 300072天津大学太赫兹研究中心, 天津 300072

联系人作者:赖慧彬(lhbcdw@163.com)

备注:赖慧彬(1992-),男,硕士研究生,主要从事太赫兹科学与技术以及材料检测方面的研究。E-mail: lhbcdw@163.com

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引用该论文

Lai Huibin,He Mingxia,Tian Tian,Sun Longling. Porosity of Tablets Based on Terahertz Spectroscopy[J]. Acta Optica Sinica, 2018, 38(6): 0630001

赖慧彬,何明霞,田甜,孙珑玲. 基于太赫兹光谱的固体片剂孔隙率研究[J]. 光学学报, 2018, 38(6): 0630001

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