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Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device

Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device

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Abstract

Optical coherence tomography (OCT) has been widely applied to the diagnosis of eye diseases during the past two decades. However, valid evaluation methods are still not available for the clinical OCT devices. In order to assess the axial resolution of the OCT system, standard model eyes with micro-scale multilayer structure have been designed and manufactured in this study. Mimicking a natural human eye, proper Titanium dioxide (TiO2) materials of particles with different concentrations were selected by testing the scattering coe±cient of PDMS phantoms. The artificial retinas with multilayer films were fabricated with the thicknesses from 9.5 to 30 micrometers using spin coating technology. Subsequently, standard OCT model eyes were accomplished by embedding the retina phantoms into the artificial frames of eyes. For ease of measurement processing, a series of model eyes were prepared, and each contained films with three kinds of thicknesses. Considering the traceability and accuracy of the key parameters of the standard model eyes, the thicknesses of multilayer structures were verified using Thickness Monitoring System. Through the experiment with three different OCT devices, it demonstrated the model eyes fabricated in this study can provide an effective evaluation method for the axial resolution of an ophthalmic OCT device.

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DOI:10.1142/s179354581850013x

基金项目:The study was supported by the National Key Research and Development Program of China (2016YFF0201005).

收稿日期:2017-10-25

修改稿日期:2018-01-08

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作者单位    点击查看

Zhenggang Cao:National Institute of Metrology, Division of Medical and Biological Measurements, Beijing 100029, P. R. China
Zengqian Ding:Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology College of Physics, Soochow University, Suzhou 215006, P. R. ChinaKey Laboratory of Advanced Optical Manufacturing, Technologies of Jiangsu Province and Key Laboratory of Modern Optical Technologies of Education Ministry of China, Soochow University, Suzhou 215006, P. R. China
Zhixiong Hu:National Institute of Metrology, Division of Medical and Biological Measurements, Beijing 100029, P. R. China
Wen Qiao:Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology College of Physics, Soochow University, Suzhou 215006, P. R. ChinaKey Laboratory of Advanced Optical Manufacturing, Technologies of Jiangsu Province and Key Laboratory of Modern Optical Technologies of Education Ministry of China, Soochow University, Suzhou 215006, P. R. China
Wenli Liu:National Institute of Metrology, Division of Medical and Biological Measurements, Beijing 100029, P. R. China
Xiaojun Chen:School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

联系人作者:Zhixiong Hu(huzhixiong@nim.ac.cn)

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引用该论文

Zhenggang Cao,Zengqian Ding,Zhixiong Hu,Wen Qiao,Wenli Liu,Xiaojun Chen. Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device[J]. Journal of Innovative Optical Health Sciences, 2018, 11(3): 1850013

Zhenggang Cao,Zengqian Ding,Zhixiong Hu,Wen Qiao,Wenli Liu,Xiaojun Chen. Model eyes with curved multilayer structure for the axial resolution evaluation of an ophthalmic optical coherence tomography device[J]. Journal of Innovative Optical Health Sciences, 2018, 11(3): 1850013

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