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不同黄疸治疗光源对体外血液中胆红素降解的影响

Effect of Various Neonatal Jaundice Therapeutic Light Sources in Degradation of Bilirubin in Vitro Blood

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摘要

为提高新生儿黄疸病的光照治疗效果,通过光谱匹配技术,设计并研制了一种新生儿黄疸治疗光源;采用研制的特殊蓝光LED光源与市售蓝光LED光源、蓝光荧光光源以及白光光源对浓度为130.932 μmol/L的体外胆红素标准液进行光照实验,光照时间分别是1,2,4,8 h,以研究胆红素的降解情况。结果表明:蓝光LED光源与蓝光荧光光源对胆红素溶液均有显著的降解效果,且自制的特殊蓝光LED光源的降解效果最佳;光源光谱是影响新生儿黄疸病治疗效果的重要因素,特殊蓝光LED能够有效降低胆红素溶液的浓度。

Abstract

In order to improve the efficacy of phototherapy for neonatal jaundice, we design and develop a neonatal jaundice phototherapy light source by spectral matching technology. In order to study the degradation of bilirubin, we use the designed special blue LED source, the ordinary blue LED source, the traditional blue source, and the white LED source to irradiate standard bilirubin solution in vitro with concentration of 130.932 μmol/L for 1 h, 2 h, 4 h and 8 h, respectively. The results show that the blue LED light source and the traditional blue light source have obvious degradation effect on the bilirubin solution, and the designed special blue LED has the best degradation effect. The key factor of phototherapy for neonatal jaundice is the spectrum of the light source,and the designed special blue LED can effectively reduce the concentration of bilirubin in vitro.

Newport宣传-MKS新实验室计划
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中图分类号:R722.17

DOI:10.3788/lop55.111701

所属栏目:医用光学与生物技术

基金项目:福建省科技计划引导性重点项目(2016H0022)、泉州市科技计划项目(2016T002)、南安市科技计划重点项目(G201212)

收稿日期:2018-03-23

修改稿日期:2018-05-24

网络出版日期:2018-05-29

作者单位    点击查看

张佳宁:华侨大学信息科学与工程学院福建省光传输与变换重点实验室, 福建 厦门 361021
郭震宁:华侨大学信息科学与工程学院福建省光传输与变换重点实验室, 福建 厦门 361021
林介本:泉州市世芯智能照明技术研究院有限公司, 福建 泉州 362302
李建鹏:华侨大学信息科学与工程学院福建省光传输与变换重点实验室, 福建 厦门 361021
陈中行:华侨大学信息科学与工程学院福建省光传输与变换重点实验室, 福建 厦门 361021
薛冬冬:华侨大学信息科学与工程学院福建省光传输与变换重点实验室, 福建 厦门 361021

联系人作者:郭震宁(znguo@hqu.edu.cn)

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引用该论文

Zhang Jianing,Guo Zhenning,Lin Jieben,Li Jianpeng,Chen Zhonghang,Xue Dongdong. Effect of Various Neonatal Jaundice Therapeutic Light Sources in Degradation of Bilirubin in Vitro Blood[J]. Laser & Optoelectronics Progress, 2018, 55(11): 111701

张佳宁,郭震宁,林介本,李建鹏,陈中行,薛冬冬. 不同黄疸治疗光源对体外血液中胆红素降解的影响[J]. 激光与光电子学进展, 2018, 55(11): 111701

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