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A photoacoustic imaging system with variable gain at different depths

A photoacoustic imaging system with variable gain at different depths

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Abstract

We established a photoacoustic imaging (PAI) system that can provide variable gain at different depths. The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound transducer. Avoltage-controlled attenuator was used to realize variable gain at different depths when acquiring PAI signals. The proof-of-concept imaging results for variable gain at different depths were achieved using specific phantoms. Both resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all depths. To further testify the function, we imaged the sagittal section of the body of in vivo nude mice. In addition, we imaged an absorption sample embedded in a chicken breast tissue, reaching a maximum imaging depth of ~4.6 cm. The results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all depths. The depth range resolution was ~1 mm, and the maximum imaging depth of our system reached ~4.6 cm. Furthermore, blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.

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DOI:10.1142/s1793545818500220

基金项目:This research was made possible with the financial support fromNational Natural Science Foundation of China (NSFC) (61675113, 61527808, 81401539, and 31271056), Science and Technology Research Program of Shenzhen City (JSGG20150331151536448, JCYJ20160428182247170, and JCYJ2017041217025 5060), Shenzhen basic research layout project (JCYJ2 0160324163759208) and the projects in Shenzhen Medical Engineering Laboratory For Human Auditory- equilibrium Function. Besides, we would like to thank Editage [www.editage.cn] for English language editing.

收稿日期:2018-02-28

修改稿日期:2018-04-26

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Tian Guan:Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua University, Shenzhen 518055, P. R. ChinaDepartment of Biomedical Engineering Tsinghua University, Beijing 100084, P. R. China
Yao Li:Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua University, Shenzhen 518055, P. R. ChinaDepartment of Biomedical Engineering Tsinghua University, Beijing 100084, P. R. China
Muqun Yang:Center of Precision Medicine and Healthcare Tsinghua-Berkeley Shenzhen Institute, Shenzhen 518055, P. R. China
Yong Jiang:Shenzhen Wisonic Medical Technology Co., Ltd. Taoyuan Street, Nanshan District, Shenzhen 518055, P. R. China
Yonghong He:Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua University, Shenzhen 518055, P. R. China

联系人作者:Tian Guan(guantian@sz.tsinghua.edu.cn)

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引用该论文

Tian Guan,Yao Li,Muqun Yang,Yong Jiang,Yonghong He. A photoacoustic imaging system with variable gain at different depths[J]. Journal of Innovative Optical Health Sciences, 2018, 11(5): 1850022

Tian Guan,Yao Li,Muqun Yang,Yong Jiang,Yonghong He. A photoacoustic imaging system with variable gain at different depths[J]. Journal of Innovative Optical Health Sciences, 2018, 11(5): 1850022

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