Journal of Innovative Optical Health Sciences, 2016, 9 (2): 1550016, Published Online: Dec. 27, 2018  

Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI

Author Affiliations
1 Beijing University of Chinese Medicine, P. R. China, 100102
2 Key Laboratory of TCM-information Engineering of State Administration of TCM Beijing 100102, P. R. China
Abstract
The present study aimed at investigating the relationship between tablet hardness and homogeneity of different Yinhuang dispersible tablets by near-infrared chemical imaging (NIR-CI) technology. The regularity of best hardness was founded between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets. The ingredients homogeneity of Yinhuang dispersible tablets could be spatially determined using basic analysis of correlation between analysis (BACRA) method and binary image. Then different hardnesses of Yinhuang dispersible tablets were measured. Finally, the regularity between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets was illuminated by quantifying the agglomerate of polyvinyl poly pyrrolidone (PVPP). The result demonstrated that the distribution of PVPP was unstable when the hardness was too large or too small, while the agglomerate of PVPP was smaller and more stable when the best tablet hardness was 75 N. This paper provided a novel methodology for selecting the best hardness in the tabletting process of Chinese Medicine Tablet.

Yifei Wang, Zhisheng Wu, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, Yanjiang Qiao. Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI[J]. Journal of Innovative Optical Health Sciences, 2016, 9(2): 1550016.

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