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Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence

Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence

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Abstract

Pulsed and continuous-wave (CW) lasers have been widely used as the light sources for photodynamic therapy (PDT) treatment. Singlet oxygen (1O2) is known to be a major cytotoxic agent in type-II PDT and can be directly detected by its near-infrared luminescence at 1270 nm. As compared to CW laser excitation, the effects of pulse width and repetition rate of pulsed laser on the kinetics and production of 1O2 luminescence were quantitatively studied during photosensitization of Rose Bengal. Significant difference in kinetics of 1O2 luminescence was found under the excitation with various pulse widths of nanosecond, microsecond and CW irradiation with power of 20mW. The peak intensity and duration of 1O2 production varied with the pulse widths for pulsed laser excitation, while the 1O2 was generated continuously and its production reached a steady state with CW excitation. However, no significant difference (P > 0:05) in integral 1O2 production was observed. The results suggest that the PDT efficacy using pulsed laser may be identical to the CW laser with the same wavelength and the same average fluence rate below a threshold in solution.

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DOI:10.1142/s179354581650019x

基金项目:This study was supported by the National Natural Science Foundation of China (61108078, 61450005, 81171633, 61036014), the Industry Research Special Funds for Public Welfare Projects (2015SQ00057) and the Fujian Provincial Natural Science Foundation (2014J07008).

收稿日期:2015-10-11

修改稿日期:2015-11-17

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作者单位    点击查看

Defu Chen:School of Information and Electronics Beijing Institute of Technology, Beijing 100081, P. R. China
Ying Wang:Department of Laser Medicine Chinese People's Liberation Army General Hospital Beijing 100853, P. R. China
Buhong Li:Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University, Fujian 350007, P. R. ChinaFujian Provincial Key Laboratory for Photonics Technology Fujian Normal University, Fujian 350007, P. R. China
Huiyun Lin:Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University, Fujian 350007, P. R. ChinaFujian Provincial Key Laboratory for Photonics Technology Fujian Normal University, Fujian 350007, P. R. China
Xuechun Lin:Laboratory of All-Solid-State Light Sources Institute of Semiconductors Chinese Academy of Sciences, Beijing 100083, P. R. China
Ying Gu:Department of Laser Medicine Chinese People's Liberation Army General Hospital Beijing 100853, P. R. China

联系人作者:Ying Gu(guyinglaser301@163.com)

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引用该论文

Defu Chen,Ying Wang,Buhong Li,Huiyun Lin,Xuechun Lin,Ying Gu. Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence[J]. Journal of Innovative Optical Health Sciences, 2016, 9(6): 1650019

Defu Chen,Ying Wang,Buhong Li,Huiyun Lin,Xuechun Lin,Ying Gu. Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence[J]. Journal of Innovative Optical Health Sciences, 2016, 9(6): 1650019

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