Journal of Innovative Optical Health Sciences, 2017, 10 (1): 1650034, Published Online: Dec. 27, 2018  

Investigation of photodamage by femtosecond laser to cells via gold nanorods

Author Affiliations
Ultrafast Laser Laboratory, Key Laboratory of Optoelectronic Information Technology, (Ministry of Education), College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, P. R. China
Abstract
Usually, only focused femtosecond (fs) lasers at near-infrared (NIR) range can induce photo-damage to transparent cells, making it difficult to treat large amount of cells by such optical methods for photostimulation. In this study, we clarify the mechanism of photodamage to cells that are co-cultured with gold nanorods (GNRs) by fs laser. The pulse duration and repetition rate of the fs laser play a key role in cell damage suggesting that the heat accumulation con-tributes to the major part for the cell damage rather than the high peak power which mainly determines the efficiency of multiphoton excitation. We further show that cellular Ca2t can also be released in this scheme, but the process is more sensitive to peak power. Our results can provide a large-scale GNR-mediated photostimulation for cell signaling modulation.

Yang Li, Hao He, Huanyu Song, Bowen Liu, Minglie Hu, Chingyue Wang. Investigation of photodamage by femtosecond laser to cells via gold nanorods[J]. Journal of Innovative Optical Health Sciences, 2017, 10(1): 1650034.

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