Journal of Innovative Optical Health Sciences, 2015, 8 (1): 1540003, Published Online: Jan. 10, 2019  

Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo

Author Affiliations
1 Department of Pharmaceutical Science & Technology College of Chemistry and Biology, Donghua University Shanghai 201620, P. R. China
2 Changhai Hospital, Second Military Medical University Shanghai 200433, P. R. China
Abstract
In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation.

Li-Jun Zhang, Lai-Xing Wang, Wei-Li Zhang, Yi-Jia Yan, Zhi-Long Chen. Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo[J]. Journal of Innovative Optical Health Sciences, 2015, 8(1): 1540003.

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!