Journal of Innovative Optical Health Sciences, 2010, 3 (1): 69–74, Published Online: Jan. 10, 2019  

DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION

Author Affiliations
1 National Laboratory of Pattern Recognition Institute of Automation, Chinese Academy of Sciences Beijing 100080, P.R. China
2 Beijing Anding Hospital Affiliate of Capital University of Medical Science Beijing 100088, Beijing, China
Abstract
Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology which is suitable for psychiatric patients. Several fNIRS studies have found abnormal brain activations during cognitive tasks in elderly depression. In this paper, we proposed a discriminative model of multivariate pattern classification based on fNIRS signals to distinguish elderly depressed patients from healthy controls. This model used the brain activation patterns during a verbal fluency task as features of classification. Then Pseudo-Fisher Linear Discriminant Analysis was performed on the feature space to generate discriminative model. Using leave-one-out (LOO) cross-validation, our results showed a correct classification rate of 88%. The discriminative model showed its ability to identify people with elderly depression and suggested that fNIRS may be an efficient clinical tool for diagnosis of depression. This study may provide the first step for the development of neuroimaging biomarkers based on fNIRS in psychiatric disorders.

YE ZHU, TIANZI JIANG, YUAN ZHOU, LISHA ZHAO. DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION[J]. Journal of Innovative Optical Health Sciences, 2010, 3(1): 69–74.

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