Journal of Innovative Optical Health Sciences, 2013, 6 (1): 1330002, Published Online: Jan. 10, 2019  

SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION¤

Author Affiliations
1 Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University, Fujian 350007, P. R. China
2 Department of Laser Medicine Chinese PLA General Hospital, Beijing 100853, P. R. China
3 Department of Medical Biophysics University of Toronto, Ontario Cancer Institute, Toronto Ontario M5G 2M9, Canada
Abstract
Singlet oxygen (1O2) is a highly reactive oxygen species involved in numerous chemical and photochemical reactions in different biological systems and in particular, in photodynamic therapy (PDT). However, the quantification of 1O2 generation during in vitro and in vivo photosensitization is still technically challenging. To address this problem, indirect and direct methods for 1O2 detection have been intensively studied. This review presents the available methods currently in use or under development for detecting and quantifying 1O2 generation during photosensitization. The advantages and limitations of each method will be presented. Moreover, the future trends in developing PDT-1O2 dosimetry will be briefly discussed.

BUHONG LI, HUIYUN LIN, DEFU CHEN, BRIAN C. WILSON, YING GU. SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION¤[J]. Journal of Innovative Optical Health Sciences, 2013, 6(1): 1330002.

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