Wavefront shaping (WFS) techniques have been used as a powerful tool to control light propagation in complex media, including multimode fibers. In this paper, we propose a new application of WFS for multimode fiber-based sensors. The use of a single multimode fiber alone, without any special fabrication, as a sensor based on the light intensity variations is not an easy task. The twist effect on multimode fiber is used as an example herein. Experimental results show that light intensity through the multimode fiber shows no direct relationship with the twist angle, but the correlation coe±cient (CC) of speckle patterns does. Moreover, if WFS is applied to transform the spatially seemingly random light pattern at the exit of the multimode fiber into an optical focus. The focal pattern correlation and intensity both can serve to gauge the twist angle, with doubled measurement range and allowance of using a fast point detector to provide the feedback. With further development, WFS may find potentials to facilitate the development of multimode fiber-based sensors in a variety of scenarios.