Journal of Innovative Optical Health Sciences, 2019, 12 (3): 1950011, Published Online: Sep. 4, 2019  

Scanning photoacoustic imaging of submucosal gastric tumor based on a long focused transducer in phantom and in vitro experiments

Author Affiliations
Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education, Fujian Provincial Key Lab of Photonic Technology, College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, Fujian, P. R. China
Abstract
Photoacoustic imaging, which can provide the maximum intensity contrast in tissue depth imaging without ionizing radiation, will be a promising imaging trend for tumor detection. In this paper, a column diffusion fiber was employed to carry a pulsed laser for irradiating stomach directly through esophagus based on the characteristics of gastric tissue structure. A long focused ultrasonic transducer was placed outside the body to detect photoacoustic signals of gastric tissue. Phantom and in vitro experiments of submucosal gastric tumors were carried out to check the sensitivity of scanning photoacoustic tomography system, including the lateral and longitudinal resolution of the system, sensitivity of different absorption coe±cient in imaging, capability of transversal detection, and probability of longitudinal detection. The results demonstrate that our innovative technique can improve the parameters of imaging. The lateral resolution reaches 2.09 mm. Then a depth of 5.5mm with a longitudinal accuracy of 0.36mm below gastric mucosa of early gastric cancer (EGC) has been achieved. In addition, the optimal absorption coe±cient differences among absorbers of system are 3.3–3.9 times. Results indicate that our photoacoustic imaging (PAI) system, is based on a long focusing transducer, can provide a potential application for detecting submucosal EGC without obvious symptoms.

Hua-Qin Wu, Hao-Yu Wang, Wen-Ming Xie, Shu-Lian Wu, Zhi-Fang Li, Xiao-Man Zhang, Hui Li*. Scanning photoacoustic imaging of submucosal gastric tumor based on a long focused transducer in phantom and in vitro experiments[J]. Journal of Innovative Optical Health Sciences, 2019, 12(3): 1950011.

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