应用激光, 2019, 39 (4): 703, 网络出版: 2019-10-12
405 nm激光诱导荧光检测系统的研制及其用于皮肤癌诊断的初步实验研究
Development of 405 nm Laser-induced Fluorescence Detector and Its Application on the Diagnosis of Skin Carcinoma
激光诱导荧光 荧光检测 5-氨基酮戊酸 光动力学荧光诊断 laser-induced fluorescence fluorescence detecting ALA photodynamic fluorescence diagnosis
摘要
研制了一种小型化便携式的激光诱导荧光的检测系统。检测系统 以 405 nm的稳谱半导体激光器作为激光光源, 荧光光纤探头和光纤作为荧光的收集系统, 光栅光谱仪作为荧光分析装置, 采集和分析经过5-氨基酮戊酸(ALA))处理后的鳞癌小鼠模型的原卟啉IX的荧光光谱, 对皮肤癌开展光动力学荧光诊断的初步实验研究。
Abstract
A compact portable laser-induced fluorescence detector, which includes an excitation source of 405nm stable spectra diode laser, a fluorescence collection module based on a fluorescence optical fiber probe and fibre, a fluorescence analysis module of a grating spectrometer. The study on the photodynamic diagnosis of squamous cell skin carcinoma of SKH-1 hairless mouse using the 405nm laser-induced fluorescence spectra of PpIX induced by ALA was done.
张玲玲, 文龙, 陈媛, 王秀丽, 李国旗, 贾峰, 王健超. 405 nm激光诱导荧光检测系统的研制及其用于皮肤癌诊断的初步实验研究[J]. 应用激光, 2019, 39(4): 703. Zhang Lingling, Wen Long, Chen Yuan, Wang xiuli, Li Guoqi, Jia Feng, Wang Jianchao. Development of 405 nm Laser-induced Fluorescence Detector and Its Application on the Diagnosis of Skin Carcinoma[J]. APPLIED LASER, 2019, 39(4): 703.