激光生物学报, 2019, 28 (5): 410, 网络出版: 2019-11-14
HCV NS5A蛋白结构及生物学功能的研究进展
The Research Progress in the Structure and Biological Function of HCV Non-structure Protein 5A
摘要
丙型肝炎是丙型肝炎病毒(HCV)感染引起的, 是导致肝硬化和肝癌的主要病因。HCV感染已成为严重危害人类健康的社会公共卫生问题。HCV非结构蛋白5A是近年来HCV抑制剂研究的重要靶点及热点, 本文对NS5A的三个结构域以及各个结构域在丙肝病毒复制、病毒颗粒组装及释放方面的生物学功能的研究进展进行了综述, 为NS5A抑制剂作用机制的研究提供了广泛的思路, 有利于对NS5A抑制剂的研制。
Abstract
Hepatitis C is caused by hepatitis C virus (HCV)infection, and is the leading cause of liver cirrhosis and liver cancer. HCV has become a serious threat to human health and become public health problems. HCV non-structure protein 5A is a target and hotspot of HCV inhibitor research in recent years. And we reviewed three domains of NS5A and the biological functions of each domain in hepatitis C virus replication, virus particle assembly and release. It provides a broad idea for the study of the mechanism of action of NS5A inhibitors, and is beneficial to the development of NS5A inhibitors.
周帆, 袁剑峰. HCV NS5A蛋白结构及生物学功能的研究进展[J]. 激光生物学报, 2019, 28(5): 410. ZHOU Fan, YUAN Jianfeng. The Research Progress in the Structure and Biological Function of HCV Non-structure Protein 5A[J]. Acta Laser Biology Sinica, 2019, 28(5): 410.