光散射学报, 2019, 31 (2): 101, 网络出版: 2020-02-11
拉曼光谱技术在药物分析领域的研究进展
Research Progress of Raman Spectroscopy in Pharmaceutical Analysis
拉曼光谱 药物分析 物质结构 定性定量 综述 Raman spectroscopy Drug analysis Material structure Qualitative and quantitative Review
摘要
拉曼光谱技术因其可有效避免样品中水的干扰、样品前处理简单、可快速无损分析以及表面增强拉曼可极大增强检测灵敏度等显著特点,在药物分析领域中的应用逐渐增多。本文旨在概述十几年来拉曼光谱技术在药物鉴别、药物定量分析、药物晶型分析、药物生产质控过程监测、药代动力学等方面的具体研究实例,对拉曼光谱技术在药物分析领域中的研究应用进行一次较为全面的综述,为之后该领域研究提供必要参考。
Abstract
Raman spectroscopy has been widely used in pharmaceutical analysis due to its remarkable characteristics such as avoiding the interference of water in samples,simplicity of sample pretreatment,rapid nondestructive analysis,and greatly enhancing the sensitivity of detection by Surface Enhanced Raman Spectroscopy.The purpose of this paper is to summarize the specific research examples of Raman spectroscopy in drug identification,drug quantitative analysis,drug crystal analysis,quality control process monitoring of drug production,pharmacokinetics and so on in the past ten years,and to make a comprehensive review of the research and application of Raman spectroscopy in the field of drug analysis,so as to provide necessary reference for future research in this field.
曹露, 朱嘉森, 管艳艳, 张卫红, 龚力, 谢方艳, 周海波, 赖志辉, 陈建. 拉曼光谱技术在药物分析领域的研究进展[J]. 光散射学报, 2019, 31(2): 101. CAO Lu, ZHU Jiasen, GUAN Yanyan, ZHANG Weihong, GONG Li, XIE Fangyan, ZHOU Haibo, LAI Zhihui, CHEN Jian. Research Progress of Raman Spectroscopy in Pharmaceutical Analysis[J]. The Journal of Light Scattering, 2019, 31(2): 101.