生命体中大部分生物分子都具有手性。生物分子的手性构象与等离激元纳米晶的局域表面等离激元共振(LSPR)通过偶极子-偶极子耦合作用，在其LSPR的位置会诱导出一个新的圆二色吸收光谱，具有这种光学活性的等离激元纳米晶称为手性等离激元纳米晶。手性等离激元纳米晶的光学响应信号的稳定性和可重复性都比较高，广泛应用在生物传感、化学传感、圆偏振器、光催化、癌症治疗等领域。手性等离激元纳米晶的制备技术一直是该领域的研究热点。然而，通过将手性分子直接吸附在等离激元纳米晶表面的方式所诱导的手性光学响应信号非常弱，故本综述聚焦于手性等离激元纳米晶的其他制备技术，包括通过手性分子或者软模板组装技术获得手性等离激元超结构；湿化学法将手性分子嵌入到单个纳米晶当中制备出核-壳型手性等离激元纳米晶，或者将手性分子的手性构象传递到无机纳米材料的结构当中制备出单个螺旋型手性等离激元纳米晶等。基于目前对手性等离激元纳米晶的最新研究进展，对其纳米制备技术作了进一步的总结和展望。

Most of the biomolecules in living organisms are chiral.The chiral conformation of biomolecules can be transferred to plasmonic nanocrystals via coupling with its localized surface plasmon resonance (LSPR),inducing a new circular dichroic peak at the LSPR position of plasmonic nanocrystals.In this review,chiral plasmonic nanocrystal is defined as they can possess the chiroptical activity.Because of its high stability and reproducible chiroptical response signal,chiral plasmonic nanocrystals have attracted great attention from basic science to applications.So far,synthesis of chiral plasmonic nanocrystals have always been hot topic in the numerous fields,such as,bio-/chemical sensing,circular polarizers,photocatalysis,cancer treatment,etc.In this review,chiral molecules on the surface of plasmonic nanocrystals inducing chiroptical response are not discussed because their weak coupling strength leads to weak chiroptical activity.We will focus on the recent fabrication technologies of chiral plasmonic nanocrystals,including (i) self-assembly of achiral plasmonic nanocrystals by chiral molecules or soft templates; (ii) chiral molecules encapsulation into a single nanocrystal is to make core-shell chiral plasmonic nanocrystal; (iii) chiral conformation of chiral molecules transferring to the structure of plasmonic nanocrystals is to fabricate a single helical chiral plasmonic nanocrystal.Finally,we have summarized and prospected the synthetic nanotechnology of chiral plasmonic nanocrystals based on the recent research achievements.