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脉冲钬激光碎石热效应的实验研究

Experimental research on thermal effect of pulse holmium laser lithotripsy

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摘要

脉冲钬激光在碎石手术中产生热效应, 由于对操作经验依赖严重, 不便于推广经验避免其副作用。为寻求医疗碎石激光的工程优选参数, 通过搭建体外碎石模型进行温升实验, 实时监测温度变化, 利用二维有限元法(FEM)求解热传输方程分析实验结果, 针对不同参数: 灌注液流速、激光功率、脉宽、频率和能量以及光纤头不同部位, 分析激光参数与热效应的变化关系。结果显示: 实验和理论计算的温度响应曲线形状基本吻合, 实验与理论峰值相对误差最大为5.75%。灌注液流速和激光功率是热效应的主要影响因素, 灌注液流速提高或激光功率降低可以有效降低热效应: 脉冲钬激光在工作的前60s内, 当灌注液流速为14~15ml/min, 功率为20W和35W时, 体外实验中产生峰值温度分别约为41.37℃和45.23℃; 流速降低为0时, 峰值温度分别提高至约49.5℃和53.8℃。另外, 实验结果表明高能低频、较长的脉冲时间产生热效应较明显。

Abstract

The pulsed holmium laser has a thermal effect in lithotripsy surgery. Due to its heavy dependence on operating experience, it’s inconvenient to promote experience to avoid its side effects. The temperature rise experiment was carried out by building an in vitro lithotripsy model with real-time monitoring of temperature changes, and the heat transfer equation was solved by two-dimensional finite element method (FEM) to analyze experiments results, for different parameters: irrigation rates, laser power, pulse width, frequency and energy, as well as the optical fiber head of different parts, analyzing the relationship between laser parameters and thermal effects for seeking medical gravel engineering optimization parameters of the laser. The results show that the shape of the temperature response curve calculated by experiment and theory is basically the same, and the maximum relative error is 5.75%. The thermal effect can be reduced effectively by increasing the irrigation rates or decreasing the laser power: The pulsed holmium laser generated peak temperatures of about 41.37℃ and 45.23℃ in vitro experiments within the first 60s when the irrigation rates was 14~15ml/min and the power was 20W and 35W. When the irrigation rate decreased to 0, the peak temperature increased to about 49.5℃ and 53.8℃, respectively. In addition, the experimental results show that high-energy, low-frequency and longer pulse time have more obvious thermal effects.

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中图分类号:TN249

所属栏目:医用光学

基金项目:国家自然科学基金(61308115); 上海市科委产学研医项目(15DZ1940400)

收稿日期:2020-02-05

修改稿日期:2020-05-16

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冯媛媛:上海理工大学医疗器械与食品学院 上海介入医疗器械工程技术研究中心, 上海 200093
陈明惠:上海理工大学医疗器械与食品学院 上海介入医疗器械工程技术研究中心, 上海 200093
谈维杰:上海理工大学医疗器械与食品学院 上海介入医疗器械工程技术研究中心, 上海 200093
王健平:上海理工大学医疗器械与食品学院 上海介入医疗器械工程技术研究中心, 上海 200093
郑刚:上海理工大学医疗器械与食品学院 上海介入医疗器械工程技术研究中心, 上海 200093

联系人作者:冯媛媛(897486562@qq.com)

备注:冯媛媛(1995-), 女 , 硕士研究生, 从事生物医学激光方面的研究。

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引用该论文

FENG Yuanyuan,CHEN Minghui,TAN Weijie,WANG Jianping,ZHENG Gang. Experimental research on thermal effect of pulse holmium laser lithotripsy[J]. Optical Technique, 2020, 46(4): 507-512

冯媛媛,陈明惠,谈维杰,王健平,郑刚. 脉冲钬激光碎石热效应的实验研究[J]. 光学技术, 2020, 46(4): 507-512

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