808 nm laser triggered self-monitored photo-thermal therapeutic nano-system Y2O3: Nd3+/Yb3+/Er3+@SiO2@Cu2S

Zhiyu Zhang; Hao Suo; Xiaoqi Zhao; Chongfeng Guo

doi:doi:10.1364/PRJ.8.000032

Photonics Research, 2020, 8 (1): 01000032, Published Online: Dec. 10, 2019

808 nm laser triggered self-monitored photo-thermal therapeutic nano-system Y₂O₃: Nd³⁺/Yb³⁺/Er³⁺@SiO₂@Cu₂S Download： 1220次

Zhiyu Zhang Hao Suo Xiaoqi Zhao Chongfeng Guo ^*

Author Affiliations

National Key Laboratory of Photoelectric Technology and Functional Materials (Culture Base) in Shaanxi Province, National Photoelectric Technology and Functional Materials & Application of Science and Technology International Cooperation Base, Institute of Photonics & Photon-Technology, Northwest University, Xi’an 710069, China

Abstract

A multifunctional photo-thermal therapeutic nano-platform

Y_{2} O_{3} : {Nd}^{3 +} / {Yb}^{3 +} / {Er}^{3 +} @ {SiO}_{2} @ {Cu}_{2} S

(YR-Si-

{Cu}_{2} S

) was designed through a core–shell structure, expressing the function of bio-tissue imaging, real-time temperature detection, and photo-thermal therapy under 808 nm light excitation. In this system, the core

Y_{2} O_{3} : {Nd}^{3 +} / {Yb}^{3 +} / {Er}^{3 +}

(YR) takes the responsibility of emitting optical information and monitoring temperature, while the shell

{Cu}_{2} S

nano-particles carry most of the photo-thermal conversion function. The temperature sensing characteristic was achieved by the fluorescence intensity ratio using the thermally coupled energy levels (TCLs)

{}^{4}{S_{3 / 2}} / {{}^{2}H}_{11 / 2}

{Er}^{3 +}

, and its higher accuracy for real-time temperature measurement in the bio-tissue than that of an infrared thermal camera was also proved by sub-tissue experiments. Furthermore, the photo-thermal effect of the present nano-system

Y_{2} O_{3} : {Nd}^{3 +} / {Yb}^{3 +} / {Er}^{3 +} @ {SiO}_{2} @ {Cu}_{2} S

was confirmed by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) ablation. Results indicate that YR-Si-

{Cu}_{2} S

has application prospect in temperature-controlled photo-thermal treatment and imaging in bio-tissues.

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Zhiyu Zhang, Hao Suo, Xiaoqi Zhao, Chongfeng Guo. 808 nm laser triggered self-monitored photo-thermal therapeutic nano-system Y₂O₃: Nd³⁺/Yb³⁺/Er³⁺@SiO₂@Cu₂S[J]. Photonics Research, 2020, 8(1): 01000032.

808 nm laser triggered self-monitored photo-thermal therapeutic nano-system Y₂O₃: Nd³⁺/Yb³⁺/Er³⁺@SiO₂@Cu₂S Download： 1220次

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