中国激光, 2020, 47 (2): 0207016, 网络出版: 2020-02-21
生物医学光声显微成像:技术和应用进展 下载: 3076次
Biomedical Photoacoustic Microscopy: Advances in Technology and Applications
生物医学 光声成像 光声显微成像 多模态 结构成像 功能成像 分子成像 biotechnology photoacoustic tomography photoacoustic microscopy multimodality structural imaging functional imaging molecular imaging
摘要
光声成像兼具光学成像对比度高和超声成像在深层生物组织中分辨率高等优点,是近年来迅速发展起来的一种生物医学成像模态。光声显微成像(PAM)是光声成像的一种重要实现方式,利用其可以无创提供活体生物组织结构和功能信息的优点,研究人员已开展了临床前和临床应用研究。为了使不同领域的研究人员了解这一快速发展的成像技术,本文综述了光声显微成像的发展现状、最新技术和研究进展。文章首先介绍了PAM的基本原理和典型的系统实现,然后概述了包括空间分辨率、成像深度、扫描方式、信号探测手段和多模态成像等方面的重要研究进展,接着阐述了PAM在生物医学领域的应用现状,最后总结了其未来发展面临的挑战。
Abstract
Combing the advantages of optical and ultrasound imaging, photoacoustic tomography is an emerging, fast growing biomedical imaging modality, possessing high resolution, superb contrast and deep tissue penetration. Photoacoustic microscopy (PAM) is an important embodiment of photoacoustic tomography. It has been extensively studied for preclinical and clinical applications by taking advantage of its ability to provide anatomical and functional information of live bodies noninvasively. To make people better understand the emerging technique, this review reviews the development status, latest technology, and application advances of PAM. We first introduce the working principle and typical system configurations and then discuss major advances in spatial resolution, imaging depth, scanning methods, signal detection methods, and multimodality imaging. Subsequently, we review the current status of biomedical applications of PAM. Finally, technical challenges of PAM in the translation to clinical settings are discussed.
龙晓云, 田超. 生物医学光声显微成像:技术和应用进展[J]. 中国激光, 2020, 47(2): 0207016. Long Xiaoyun, Tian Chao. Biomedical Photoacoustic Microscopy: Advances in Technology and Applications[J]. Chinese Journal of Lasers, 2020, 47(2): 0207016.