In this work, SF₆ as a Raman-active medium is investigated to generate a multispectral Raman laser by the combination of cascade stimulated Raman scattering (SRS) and four wave mixing. The Raman frequency comb from the 10th-order anti-Stokes to the 9th-order Stokes was generated, and its spectral range covered 377–846 nm. The photon conversion efficiency of 16.4% for the first Stokes was achieved, and the Raman gain coefficient at 1.5 MPa of SF₆ under the 532 nm pump laser was calculated to be 0.83 cm/GW by the SRS threshold comparison with H₂. Using helium as the carrier gas, the thermal effect of the SF₆ Raman laser was improved dramatically under a repetition rate of 10 Hz.