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非标记、定量化穆勒矩阵偏振成像在辅助临床诊断中的应用 (特邀综述)

Mueller Matrix Polarimetry: A Label-Free, Quantitative Optical Method for Clinical Diagnosis (Invited)

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摘要

近年来,随着新型光学器件的出现与数据处理能力的提升,偏振光学成像技术在生物医学领域的应用逐渐增多。穆勒矩阵因可以完备地表述样品的偏振信息,且测量装置可与传统光学仪器兼容,非常适合于生物医学样品的研究。同时,与非偏振光学方法相比,穆勒矩阵对亚波长结构敏感,还可以额外提供包括双折射、二向色性在内的样品的光学各向异性信息。介绍了穆勒矩阵偏振成像的基本理论与装置,包括穆勒矩阵参量的提取、背向散射成像、偏振显微成像、偏振内窥与偏振染色等在生物医学检测中具有一定应用潜力的方法和技术,并展示了穆勒矩阵成像在肝癌、乳腺癌、胃肠肿瘤等多种病理组织辅助诊断中的最新研究进展。穆勒矩阵偏振成像作为一种非标记、定量化、无损伤的快速检测技术,在生物医学领域显示出了广阔的应用前景。

Abstract

Of late, with the emergence of new optical devices and technological advances in data processing, polarization techniques are being increasingly used in biomedicine. Mueller matrix calculus is suitable for describing the polarization properties of biomedical specimens because of its mathematical completeness and compatibility with common optical equipment. Compared with traditional non-polarization optical methods, Mueller matrix polarimetry is sensitive to the scattering induced by subwavelength structures and can provide more information about anisotropic optical properties, including the birefringence and diattenuation of a sample. In this review, we introduce Mueller matrix calculus and related technologies that have great application potential in biomedical studies, including the Mueller matrix decomposition and transformation methods, transmission Mueller matrix microscopes, backscattering Mueller matrix imaging equipment, Mueller matrix endoscopes, and polarization staining techniques. Further, we summarize the improvements in clinical diagnosis made using Mueller matrix polarimetry, such as detection of liver cancer, gastrointestinal cancer, and breast ductal carcinoma tissues. As a label-free, noninvasive, quantitative, and rapid imaging method, Mueller matrix polarimetry has broad application prospects in biomedical studies and clinical diagnosis.

Newport宣传-MKS新实验室计划
补充资料

中图分类号:O436.3

DOI:10.3788/CJL202047.0207001

所属栏目:生物医学光子学与激光医学

基金项目:国家自然科学基金、深圳市科技计划;

收稿日期:2019-11-11

修改稿日期:2019-12-11

网络出版日期:2020-02-01

作者单位    点击查看

沈元星:清华大学深圳国际研究生院, 广东省偏振光学检测与成像工程技术研究中心,深圳市无损监测与微创医学技术重点实验室, 光学检测与成像研究所, 广东 深圳 518055清华大学生物医学工程系, 北京 100084
姚悦:清华大学清华-伯克利深圳学院, 广东 深圳 518071
何宏辉:清华大学深圳国际研究生院, 广东省偏振光学检测与成像工程技术研究中心,深圳市无损监测与微创医学技术重点实验室, 光学检测与成像研究所, 广东 深圳 518055
刘少雄:深圳市第六人民医院(南山医院), 华中科技大学协和深圳医院, 广东 深圳 518052
马辉:清华大学深圳国际研究生院, 广东省偏振光学检测与成像工程技术研究中心,深圳市无损监测与微创医学技术重点实验室, 光学检测与成像研究所, 广东 深圳 518055清华大学清华-伯克利深圳学院, 广东 深圳 518071清华大学物理系, 北京 100084

联系人作者:马辉(mahui@tsinghua.edu.cn)

备注:国家自然科学基金、深圳市科技计划;

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引用该论文

Shen Yuanxing,Yao Yue,He Honghui,Liu Shaoxiong,Ma Hui. Mueller Matrix Polarimetry: A Label-Free, Quantitative Optical Method for Clinical Diagnosis[J]. Chinese Journal of Lasers, 2020, 47(2): 0207001

沈元星,姚悦,何宏辉,刘少雄,马辉. 非标记、定量化穆勒矩阵偏振成像在辅助临床诊断中的应用[J]. 中国激光, 2020, 47(2): 0207001

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