鉴于动物研究在基础研究中的重要作用,近年来几种在人眼视网膜成像中广泛应用的光学成像技术也在动物视网膜中得到了成功应用,无需组织学切片即可实现对动物视网膜的高精度细胞级别成像,这为使用动物视网膜进行基础研究的科研工作者提供了强有力的工具。与之相应的是,动物视网膜的研究工作中也开发了一些新型的、可以应用于人眼的成像技术,或者增强了对人眼视网膜功能机理的理解。结合自身在小鼠视网膜多种活体成像方式上的技术积累和研究经历,从若干方面阐述了近年来在小鼠和人眼视网膜高精度光学成像领域出现的技术突破,侧重于展示当前技术所能达到的成像水平,希望能起到抛砖引玉的效果,为促进动物视网膜影像和人眼视网膜影像之间的相互交流和相互促进起到积极的作用。

Animal studies play very important roles in the basic science research. Recently, several optical imaging methods, which are widely adopted in human retinal imaging, have been successfully applied into animal retina researches. By providing high-resolution cellular details about the retina without the need for histological section, these optical imaging methods provide powerful tools for researchers to study using the animal retina. Correspondingly, several new technologies have been developed for animal retina researches, which are also applicable for human retinal imaging, or provide new insights in understanding the human retina function mechanism. Based on their own research experiences in in vitro optical imaging methods for mouse retinas, the authors review several latest break-through technology developments in animal and human retinal imaging with high resolution and with a focus on demonstration of the “can-do” ability of the current technologies, hoping it will provide new insights to promote the advancements for ophthalmic imaging in both species.