中国激光, 2020, 47 (2): 0207006, 网络出版: 2020-02-21
光学成像技术在光动力剂量监测中的应用进展 下载: 1585次特邀综述
Advances in Optical Imaging for Monitoring Photodynamic Therapy Dosimetry
医用光学 光动力疗法 光学成像 剂量 监测 临床应用 medical optics photodynamic therapy optical imaging dose monitoring clinical application
摘要
光动力疗法(PDT)作为选择性治疗恶性肿瘤和良性疾病的精准靶向疗法,已获得了广泛的临床应用。如何利用先进的光学成像技术实现对PDT剂量的实时监测,是开展PDT个性化精准治疗的理论基础。本文介绍了PDT治疗过程中光敏剂、氧、单线态氧以及血管响应等所需监测的4个重要参量,重点总结了用于实时监测PDT参量的光学成像技术,并比较分析了这些技术的优势和局限性,最后讨论了光学成像技术在PDT临床转化应用中面临的挑战。
Abstract
Photodynamic therapy (PDT) has been widely used as a precise targeted therapeutic modality in the clinical treatments of malignant tumor and benign diseases. The utilization of advanced optical imaging techniques in the real-time quantification of PDT dosimetric parameters is essential in predicting PDT efficiency and providing personalized and precise treatment. In this study, four important parameters in PDT dosimetry were introduced (i.e., photosensitizer, ground-state oxygen, singlet oxygen, and vascular response). Furthermore, the advanced optical imaging techniques currently developed for monitoring the aforementioned dosimetric parameters are summarized, and the advantages and limitations of each optical imaging technique is comparatively analyzed. Finally, challenges in clinical translation of optical imaging techniques to the clinical application of PDT are briefly discussed.
李文博, 沈毅, 李步洪. 光学成像技术在光动力剂量监测中的应用进展[J]. 中国激光, 2020, 47(2): 0207006. Li Wenbo, Shen Yi, Li Buhong. Advances in Optical Imaging for Monitoring Photodynamic Therapy Dosimetry[J]. Chinese Journal of Lasers, 2020, 47(2): 0207006.