激光与光电子学进展, 2020, 57 (3): 030002, 网络出版: 2020-02-17   

基于内标法的表面增强拉曼散射定量分析 下载: 1753次

Quantitative Analysis of Surface-Enhanced Raman Scattering Based on Internal Standard Method
作者单位
重庆大学光电工程学院光电技术及系统教育部重点实验室, 重庆 400044
摘要
表面增强拉曼散射(SERS)是一种高效的分子光谱检测技术,被广泛应用于微痕量物质检测甚至单分子检测,涉及化学、生命科学和药物分析等多个领域。但“热点”的非均匀性、化学效应的非稳定性、分子数量的不确定性等会导致增强拉曼信号波动性增大,很难用于定量分析。从“热点”效应、化学效应、分子吸附、内标添加模式四个方面,综述了内标法原理、基底性能改善和三种内标物添加的模式(外部添加、核-内标分子-壳模式和基底自标定模式)。
Abstract
Surface-enhanced Raman scattering (SERS) is a highly efficient molecular spectroscopy technique widely used to detect trace species in studies in many fields such as chemistry, life sciences, and pharmaceutical analysis. However, the non-uniformity of “hot spots,” instability of chemical effects, and uncertainty of the number of molecules increase the volatility of Raman signals, which presents difficulty in their use for quantitative analysis. This paper introduces the principle of an internal standard method, improvement of substrate performance, and the modes for adding three internal standards, including external addition mode, core-internal standard-shell modes, and self-calibrating substrate mode, from the following four aspects: “hot spot” effect, chemical effect, molecular adsorption, and internal standard addition mode.

邢豪健, 尹增鹤, 张洁, 朱永. 基于内标法的表面增强拉曼散射定量分析[J]. 激光与光电子学进展, 2020, 57(3): 030002. Haojian Xing, Zenghe Yin, Jie Zhang, Yong Zhu. Quantitative Analysis of Surface-Enhanced Raman Scattering Based on Internal Standard Method[J]. Laser & Optoelectronics Progress, 2020, 57(3): 030002.

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