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吲哚菁绿与亚甲基蓝对生物组织激光钎焊强度及热损伤的影响

Effects of Indocyanine Green and Methylene Blue on Tensile Strength and Thermal Damage of Laser Biological Tissue Soldering

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摘要

激光生物组织焊接与传统的缝合相比具有手术时间短、伤口愈合快、组织损伤少、无需拆线等优点。为了改善激光生物组织的焊接强度与质量,增加组织全厚度方向的激光吸收率,并探究染料对生物组织激光钎焊强度及热损伤的影响,以牛血清蛋白溶液为基体,壳聚糖为稳定剂,吲哚菁绿、亚甲基蓝为染色剂,利用波长为1064 nm的Nd∶YAG激光器对施加助焊剂的离体猪皮肤进行钎焊实验,并对焊接效果进行对比。结果表明:吲哚菁绿与亚甲基蓝是激光焊接过程中效果显著的有机生色团,能在促进光热转换效率、增大焊接强度的同时降低热损伤。

Abstract

In comparison with the traditional suturing, laser biological tissue welding has the following advantages: shorter operation time, faster wound healing, less tissue damage, and no thread removal. To improve the strength and quality of laser soldering of biological tissues, increase the laser absorptivity in the direction of full-thickness, and explore the effects of dyes on the strength and thermal damage of laser soldering of biological tissues, we use the bovine serum albumin solution as the matrix, chitosan as the stabilizer, and indocyanine green and methylene blue as dyes. We use a Nd∶YAG laser (1064 nm) to weld the skin in vitro with flux and compare the welding effect of flux. Results show that indocyanine green and methylene blue are significant organic chromophores for laser welding. They promote the efficiency of photothermal conversion, improve the welding strength, and reduce thermal damage.

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中图分类号:TN249

DOI:10.3788/CJL201946.1207002

所属栏目:生物医学光子学与激光医学

基金项目:国家基础科研项目;

收稿日期:2019-07-08

修改稿日期:2019-08-29

网络出版日期:2019-12-01

作者单位    点击查看

李聪:南京理工大学材料科学与工程学院, 江苏 南京 210094
王克鸿:南京理工大学材料科学与工程学院, 江苏 南京 210094
黄俊:南京理工大学材料科学与工程学院, 江苏 南京 210094

联系人作者:王克鸿(wkh1602@126.com); 黄俊(wkh1602@126.com);

备注:国家基础科研项目;

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引用该论文

Li Cong,Wang Kehong,Huang Jun. Effects of Indocyanine Green and Methylene Blue on Tensile Strength and Thermal Damage of Laser Biological Tissue Soldering[J]. Chinese Journal of Lasers, 2019, 46(12): 1207002

李聪,王克鸿,黄俊. 吲哚菁绿与亚甲基蓝对生物组织激光钎焊强度及热损伤的影响[J]. 中国激光, 2019, 46(12): 1207002

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