中国激光, 2020, 47 (2): 0207011, 网络出版: 2020-02-21
多种形态结构的光学纳米生物传感器及其在肿瘤筛查中的应用 下载: 1348次特邀综述
Optical Nanobiosensors with Different Structures and Their Applications in Tumor Screening
医用光学 生物传感器 纳米技术 壳核纳米粒子 肿瘤标志物检测 medical optics biosensors nanotechnology core-shell nanoparticles tumor marker detection
摘要
肿瘤是现代医学亟须克服的难题,肿瘤的早筛查、早治疗始终是临床医学的重大需求。本文评述了基于纳米粒子、纳米线、纳米管和纳米阵列来检测肿瘤标志物的纳米生物传感器的基本原理和检测特性。壳核纳米粒子具有丰富的修饰功能;纳米线多被制成场效应管以检测肿瘤标志物;基于良好的尺度效应,纳米管多用于载体运输及平台检测;金属纳米阵列和金属氧化物纳米阵列可利用电化学阻抗谱的原理来检测癌细胞。除由不同形态结构决定的优势和应用特点以外,与传统的检测方法相比,光学纳米生物传感器检测癌细胞具有快速便捷、检出质量浓度低等优势,因而在医学检测和肿瘤研究中得到了一定的应用,具有较大的发展潜力。
Abstract
Tumor is an important problem that modern medicine needs to overcome. Early screening and treatment of tumor require immediate attention in clinical practice. Therefore, this paper describes the basic principles and detection characteristics of several common tumor marker nanobiosensors based on nanoparticle, nanowire, nanotube, and nanoarray material. Core-shell nanoparticles have abundant modification function. Nanowires are often made into field-effect tube to detect tumor markers. Based on the scale effect, nanotubes are primarily used in transport of carriers and detection platform. Metal and metal-oxide nanoarrays can detect cancer cells using the principle of electrochemical impedance spectroscopy. In addition to the advantages and application characteristics determined by different structures, nanobiosensors have the overall advantages of rapid and convenient detection of tumor cells and low detection limit compared with traditional detection methods. Therefore, nanobiosensors offer great potential in medical detection and tumor research.
姜天舒, 张若彤, 董昌梓, 金伟秋, 贾明龙, 张镇西. 多种形态结构的光学纳米生物传感器及其在肿瘤筛查中的应用[J]. 中国激光, 2020, 47(2): 0207011. Jiang Tianshu, Zhang Ruotong, Dong Changzi, Jin Weiqiu, Jia Minglong, Zhang Zhenxi. Optical Nanobiosensors with Different Structures and Their Applications in Tumor Screening[J]. Chinese Journal of Lasers, 2020, 47(2): 0207011.