针对医用植入体材料锆基金属玻璃在应用中存在的生物兼容性问题,采用纳秒激光在金属玻璃试样表面诱导产生点阵和沟槽两种微纳结构,然后采用细胞活性测试、细胞分布和形态观察评价两种微纳结构对锆基金属玻璃生物兼容性的改善效果,并从表面形貌方面讨论激光表面改性对生物兼容性的改善机理。结果表明:相对于原始试样,激光诱导产生的沟槽结构能够显著增强成骨细胞在试样表面的黏附性和细胞活性,这主要归功于显著增加的表面粗糙度;点阵结构对细胞活性的改善效果不理想。除此之外,在沟槽试样表面,激光诱导产生的沟槽以及在沟槽内附着的微纳结构是成骨细胞在沟槽内部或附近沿着沟槽方向分布的主要原因。

In an effort to resolve the biocompatibility problems of Zr-based bulk metallic glasses in biomedical applications as implant materials, a nanosecond laser was employed to produce dimple and groove textures on a Zr sample surface. The biocompatibility characteristics of the sample surface were evaluated by a cell viability test, cell alignment, and morphology observation. Moreover, the surface modifications induced biocompatibility enhancement mechanism were discussed from the perspective of the surface morphology evolution. The results show that, compared with an untreated sample, the laser-induced groove pattern could significantly enhance osteoblast adhesion on the sample surface and cell viability, which is mainly attributed to the remarkably improved surface roughness. However, the modification effect of the laser-induced dimple pattern on cell viability was undesirable. In addition, the laser-induced grooves and the micro-nanostructures attached in the grooves are the main reasons why the osteoblasts are distributed along the groove direction in or around the grooves.