光学学报, 2014, 34 (1): 0134001, 网络出版: 2014-01-02   

毛细管X光透镜共聚焦微束X射线荧光技术在胶囊类药品分析中的应用

Application of Confocal Micro X-Ray Fluorescence Technique Based on Polycapillary X-Ray Lens in Analyzing Medicine with Capsule
孙天希 1,2,3,*刘鹤贺 1,2,3刘志国 1,2,3彭松 1,2,3孙蔚渊 1,2,3赵为刚 1,2,3赵广翠 1,2,3何佳霖 1,2,3丁训良 1,2,3
作者单位
1 北京师范大学射线束技术与材料改性教育部重点实验室, 北京 100875
2 北京师范大学核科学与技术学院, 北京 100875
3 北京市辐射中心, 北京 100875
摘要
为了对胶囊类药品进行无损分析鉴别,利用两个多毛细管X光透镜搭建了共聚焦微束X射线荧光谱仪,两个处在共聚焦状态的透镜形成共聚焦微元,探测器只能探测到来自该共聚焦微元中的X射线信号,这有利于分别对胶囊壳和其内部药物进行原位无损元素分析,从而辨别它们的种类。分析了4种胶囊类药品对应的X射线荧光谱特征,从荧光谱图上可以看出不同胶囊类药品有不同的X射线荧光谱,对应不同的元素组成,所以可以利用胶囊内部药物对应的X射线荧光谱鉴别胶囊类药品的种类。实验证明,利用共聚焦微束X射线荧光技术可以在不破坏胶囊壳的情况下对胶囊类样品进行无损原位分析,该技术在胶囊类药品种类和真伪鉴别中具有潜在应用价值。
Abstract
The confocal micro X-ray fluorescence technology based on two polycapillary X-ray lenses is used to analyze the elements in the medicines with capsule non-destructively. In this technology, two confocal lenses form confocal volume, and only the X-rays from the confocal volume can be detected by the detector, which ensures non-destructive and in-situ analysis of elements in the capsule shell and the medicine inside to identify their species. X-ray fluorescence spectral characteristics of four types of medicines with capsule are analyzed. The experimental results show that different medicines have different X-ray fluorescence spectra, and different spectra correspond to different elemental compositions, which could be used to identify medicines. The confocal micro X-ray fluorescence technology can be used in the non-destructive and in-situ analysis of the samples with capsule, and has potential applications in identifying the types and the authenticity of medicines with capsule.
参考文献

[1] H Salem. Selective spectrophotometric determination of phenolic β-lactam antibiotics in pure forms and in their pharmaceutical formulations [J]. Anal Chim Acta, 2004, 515(2): 333-341.

[2] Azza M M Ali. Cathodic adsorptive stripping voltammetric determination of the anti-inflammatory drug indomethacin [J]. J Pharm Biomed Anal, 1999, 18(6): 1005-1012.

[3] B M Patterson, G J Havrilla. Integrating X-ray fluorescence and infrared imaging microspectroscopies for comprehensive characterization of an acetaminophen model harmaceutical [J]. Appl Spectrosc, 2006, 60(5): 471-478.

[4] 张竹青, 王强, 花国然, 等. YAG激光频率对a:H-Si薄膜微晶化的影响 [J]. 激光与光电子学进展, 2013, 50(2): 021406.

    Zhang Zhuqing, Wang Qiang, Hua Guoran, et al.. Influence of YAG laser frequency on a:H-Si thin films micro-crystallization [J]. Laser & Optoelectronics Progress, 2013, 50(2): 021406.

[5] 郭培源, 林岩, 付妍, 等. 基于近红外光谱技术的猪肉新鲜度等级研究 [J]. 激光与光电子学进展, 2013, 50(3): 033002.

    Guo Peiyuan, Lin Yan, Fu Yan, et al.. Research on freshness level of meat based on near-infrared spectroscopic technique [J]. Laser & Optoelectronics Progress, 2013, 50(3): 033002.

[6] S M A Azeem, S M M Attaf, M F El-Shahat, et al.. Acetylacetone phenylhydrazone functionalized polyurethane foam: determination of copper, zinc and manganese in environmental samples and pharmaceutics using flame atomic absorption spectrometry [J]. React Funct Polym, 2013, 73(1): 182-191.

[7] F J Antosz, Y Q Xiang, A R Diaz, et al.. The use of total reflectance X-ray fluorescence (TXRF) for the determination of metals in the pharmaceutical industry [J]. J Pharm Biomed Anal, 2012, 62: 17-22.

[8] 王健, 谢自力, 张韵, 等. 利用X射线衍射研究Mg掺杂的InN的快速退火特性 [J]. 中国激光, 2013, 40(1): 0106003.

    Wang Jian, Xie Zili, Zhang Yun, et al.. Rapid thermal annealing characteristics of Mg-doped InN by X-ray diffraction [J]. Chinese J Lasers, 2013, 40(1): 0106003.

[9] B J Shaw, D J Semin, M E Rider, et al.. Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis [J]. J Pharm Biomed Anal, 2012, 63: 151-159.

[10] H E Lee, M J Lee, W S Kim, et al.. In-line monitoring and interpretation of an indomethacin anti-solvent crystallization process by near-infrared spectroscopy (NIRS) [J]. Int J Pharm, 2011, 420(2): 274-281.

[11] N Lewen. The use of atomic spectroscopy in the pharmaceutical industry for the determination of trace elements in pharmaceuticals [J]. J Pharm Biomed Anal, 2011, 55(4): 653-661.

[12] 徐磊, 夏海平, 胡敏杰, 等. 纳米硫化铜近红外吸收材料[J]. 光学学报, 2013, 33(1): 0116001.

    Xu Lei, Xia Haiping, Hu Minjie, et al.. Nano-copper sulfide for absorbing near infrared light [J]. Acta Optica Sinica, 2013, 33(1): 0116001.

[13] 胡文杰, 贾红宝, 孙菁华, 等. 溶胶凝胶法制备用于氟磷酸盐玻璃的氟化镁减反射膜 [J]. 光学学报, 2013, 33(5): 0531001.

    Hu Wenjie, Jia Hongbao, Sun Jinghua, et al.. Magnesium fluoride anti-reflective films for fluorophosphate glass prepared by sol-gel method [J]. Acta Optica Sinica, 2013, 33(5): 0531001.

[14] 姜来新, 逯鑫淼, 王阳, 等. 锑铋合金薄膜的光学常数 [J]. 中国激光, 2012, 39(9): 0907001.

    Jiang Laixin, Lu Xinmiao, Wang Yang, et al.. Optical constants of antimony-bismuth alloy films [J]. Chinese J Lasers, 2012, 39(9): 0907001.

[15] 孙天希, 刘志国, 李玉德, 等. 毛细管X光会聚透镜在潜指纹提取中的应用 [J]. 光学学报, 2011, 31(4): 0434001.

    Sun Tianxi, Liu Zhiguo, Li Yude, et al.. Application of capillary focusing X-ray lens in obtaining latent fingerprint [J]. Acta Optica Sinica, 2011, 31(4): 0434001.

[16] Tianxi Sun, Xunliang Ding. Measurements of energy dependence of properties of polycapillary X-ray lens by using organic glass as a scatterer [J]. J Appl Phys, 2005, 97(12): 124904.

[17] Tianxi Sun, Meirong Zhang, Xunliang Ding, et al.. Characterization of polycapillary X-ray lens for application in confocal three-dimensional energy dispersive micro X-ray diffraction experiments [J]. J Appl Crystallogr, 2007, 40(6): 1169-1173.

[18] Tianxi Sun, Zhiguo Liu, Yude Li, et al.. Size-resolved source apportionment of aerosol particles with a confocal micro X-ray fluorescence spectrometer [J]. Appl Spectrosc, 2011, 65(12): 1398-1402.

孙天希, 刘鹤贺, 刘志国, 彭松, 孙蔚渊, 赵为刚, 赵广翠, 何佳霖, 丁训良. 毛细管X光透镜共聚焦微束X射线荧光技术在胶囊类药品分析中的应用[J]. 光学学报, 2014, 34(1): 0134001. 孙天希, 刘鹤贺, 刘志国, 彭松, 孙蔚渊, 赵为刚, 赵广翠, 何佳霖, 丁训良. Application of Confocal Micro X-Ray Fluorescence Technique Based on Polycapillary X-Ray Lens in Analyzing Medicine with Capsule[J]. Acta Optica Sinica, 2014, 34(1): 0134001.

本文已被 7 篇论文引用
被引统计数据来源于中国光学期刊网
引用该论文: TXT   |   EndNote

相关论文

加载中...

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!