A miniaturized fluorescence imaging device for rapid early skin cancer detection

Jingyue Pan; Qingquan Liu; Hao Sun; Weibo Zheng; Peiru Wang; Long Wen; Junli Duan; Zhiyi Xuan; Xiang Yu; Shaowei Wang; Xiuli Wang; Tao Zhang; Wei Lu

doi:doi:10.1142/s1793545820500261

Journal of Innovative Optical Health Sciences, 2021, 14 (2): 2050026, Published Online: Apr. 7, 2021

A miniaturized fluorescence imaging device for rapid early skin cancer detection

论文大纲

Jingyue Pan ¹Qingquan Liu ^2,3,3Hao Sun ¹Weibo Zheng ¹Peiru Wang ⁴Long Wen ⁴Junli Duan ⁵Zhiyi Xuan ^2,3,3Xiang Yu ¹Shaowei Wang ^2,3,*Xiuli Wang ⁴Tao Zhang ¹Wei Lu ^2,3,3

Author Affiliations

¹ Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, P. R. China

² State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, P. R. China

³ School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China

⁴ Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200071, P. R. China

⁵ Department of Gerontology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, P. R. China

Protoporphyrin IX coaxial design skin cancer

Abstract

Fluorescence imaging is very useful for skin cancer lesions detection because of its properties of noninvasion and fast imaging. However, conventional fluorescence imaging devices' excitation light source and camera are usually separated, which will cause problems such as complicated structure, large volume, and poor illumination homogeneity. In this paper, we introduce a miniature portable fluorescence imaging device to diagnose skin cancer. A coaxial design has been introduced to combine the exciting light source and fluorescence receiver as an integral part, which significantly reduces the size of the device and ensures illumination homogeneity. The volume of the device is less than 3.5 × 3.5 × 9.5 cm³ with weight of 150 g, and the total power (including the excitation lamp) is only 1.5 W. It is used to detect the squamous cell carcinoma mice for demonstration. The results show that the location of the cancer lesions can be easily distinguished from the images captured by the device. It can be efficiently used to detect early skin tumors with noninvasion. It also has prospects to be integrated with other diagnostic methods such as ultrasound probe, for multiple diagnose of skin tumors thanks to its miniature size.

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Jingyue Pan, Qingquan Liu, Hao Sun, Weibo Zheng, Peiru Wang, Long Wen, Junli Duan, Zhiyi Xuan, Xiang Yu, Shaowei Wang, Xiuli Wang, Tao Zhang, Wei Lu. A miniaturized fluorescence imaging device for rapid early skin cancer detection[J]. Journal of Innovative Optical Health Sciences, 2021, 14(2): 2050026.

A miniaturized fluorescence imaging device for rapid early skin cancer detection

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