Chinese Optics Letters, 2019, 17 (4): 041701, Published Online: Apr. 3, 2019   

Spectral domain optical coherence tomography with sub-micrometer sensitivity for measurement of central corneal thickness Download: 686次

Author Affiliations
1 School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China
2 School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China
3 Experiment Education Center, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China
Abstract
We demonstrated a method for measurement of central corneal thickness (CCT) with a sub-micrometer sensitivity using a spectral domain optical coherence tomography system without needing a super broad bandwidth light source. By combining the frequency and phase components of Fourier transform, the method is capable of measurement of a large dynamic range with a high sensitivity. Absolute phases are retrieved by comparing the correlations between the detected and simulated interference fringes. The phase unwrapping ability of the present method was quantitatively tested by measuring the displacement of a piezo linear stage. The human CCTs of six volunteers were measured to verify its clinical application. It provides a potential tool for clinical diagnosis and research applications in ophthalmology.

Lida Zhu, Yi Wang, Yi Yuan, Hongxian Zhou, Yuqian Zhao, Zhenhe Ma. Spectral domain optical coherence tomography with sub-micrometer sensitivity for measurement of central corneal thickness[J]. Chinese Optics Letters, 2019, 17(4): 041701.

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