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Compact long-working-distance laser diode-based photoacoustic microscopy with a reflective objective [Early Posting]

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摘要

Photoacoustic microscopy (PAM) has quickly developed into a noninvasive biomedical imaging technique to achieve the detection, diagnosis, and monitoring. Compared with Q-switched Nd: YAG or OPO lasers, using a low cost and small size laser diode (LD) as an alternative light source, is conducive to achieve the miniaturization and integration for preclinical transformation. However, LD’s low peak output power needs the high numerical aperture objective to attain tight focus, which limits the working distance (WD) of the system in only 2-3 millimeters, resulting in not achieving the backward coaxial confocal mode. Here, we present a compact visible LD-based PAM system with a reflective objective to achieve a 22 mm long WD and a 10 µm lateral resolution. Different depth subcutaneous microvascular networks in label-free mouse ears have been successfully reappeared in vivo with a SNR up to 14 dB by a confocal alignment. It will be a promising tool to develop into a handy tool for subcutaneous blood vessel imaging.

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作者单位:

    Guangdong University of Technology
    Guangdong University of Technology - University Town Campus
    Jiangxi Science and Technology Normal University
    Jiangxi Science and Technology Normal University
    Guangdong University of Technology
    Guangdong University of Technology

引用该论文

Deng Lijun,Chen Qi,Bai Yang,Liu Guodong,Zeng Lvming,Ji Xuanrong. Compact long-working-distance laser diode-based photoacoustic microscopy with a reflective objective[J].Chinese Optics Letters,2021,19(7):07.