Optical fibers have been widely applied to telecommunication, imaging, lasers, and sensing. Among the different types of fibers, photonic crystal fibers (PCFs), also called microstructured optical fibers, characterized by air holes arranged along the length of fibers have experienced tremendous advance due to their unique advantages. They are regarded as a desirable platform to excite surface plasmon resonance (SPR) because of easy realization of phase matching conditions between the fundamental core mode and the plasmonic mode, which plays a critical role in miniaturization and integration of SPR sensors. In this mini-review, the current status of PCF sensors based on SPR is summarized. The theory of SPR is discussed, and simulation methods for PCF-SPR sensors are described. The important parameters including the refractive index detection range, resonance wavelength, and spectral sensitivity responsible for the sensing properties of PCF-SPR sensors are reviewed. The fabrication and the comparison of performances are also illustrated, and, finally, the challenges and future perspectives are outlined.