激光与光电子学进展, 2017, 54 (1): 011101, 网络出版: 2017-01-17
基于补偿干涉仪的串联式全场光学相干层析系统
Compensation Interferometer Based Tandem Full-Field Optical Coherence Tomography System
成像系统 相干光学 全场光学相干层析 串联式结构 补偿干涉仪 生物医学成像 imaging systems coherence optics full-field optical coherence tomography tandem structure compensation interferometer biomedical imaging
摘要
提出了一种基于补偿干涉仪的串联式全场光学相干层析(FF-OCT)系统。该系统包含共光路式探测干涉仪和双臂式补偿干涉仪, 前者用于探测样品的后向散射光, 后者用于补偿探测干涉仪两臂的光程差。采用宽带卤素灯光源和大数值孔径显微物镜进行成像; 利用单片机进行相位调制, 以便从干涉图像中获得样品的正面层析图像。进行了洋葱细胞的光学层析实验, 验证了系统的可行性。探测干涉仪基于共路式结构, 体积小, 对外界运动等的影响不敏感。使用光纤连接两个干涉仪, 可实现手持式探测干涉仪, 对实现内窥式探头具有重要意义。
Abstract
A tandem full-field optical coherence tomography (FF-OCT) system based on compensation interferometer is proposed. The new system consists of a common-path detection interferometer and a double-armed compensation interferometer. The former is used to detect the backscattered light from the sample, and the latter is used to compensate the optical path difference of two arms of the detection interferometer. A broadband halogen light source and a large numerical aperture microscopic objective are used for imaging. When the phase is modulated by a single chip-based control device, en-face tomography images of samples are obtained from the interference images. The experiment of optical tomography imaging for onion cells is conducted to demonstrate the feasibility of the proposed system. The detection interferometer based on the common-path structure has a small size and it is not sensitive to external environment. The handheld detection interferometer can be achieved when we use a fiber to connect two interferometers, and it has great importance in achieving endoscopic probes.
郭英呈, 高万荣, 朱越. 基于补偿干涉仪的串联式全场光学相干层析系统[J]. 激光与光电子学进展, 2017, 54(1): 011101. Guo Yingcheng, Gao Wanrong, Zhu Yue. Compensation Interferometer Based Tandem Full-Field Optical Coherence Tomography System[J]. Laser & Optoelectronics Progress, 2017, 54(1): 011101.