为了提高光学分子影像与计算机断层扫描(CT)影像的耦合图像质量,基于自由曲面光学技术建立了光学分子影像与CT影像肿瘤病灶组织的自由曲面光学通道,实现了双模态影像融合显示。采用肿瘤病灶组织的微进、多空间、多焦点自由曲面光学曲面镜头与成像面的设计方法,建立双模态影像融合镜头与成像面的微分方程,解出病灶组织自由曲面的光学曲面光焦度变化曲线。采用反求工程中的自由曲面光学重构技术,对病灶组织自由曲面的光学通道曲面进行离散和重建,提高了光学分子影像与CT影像双模态融合的图像质量。采用自由曲面光学通道技术融合显示光学分子影像与CT影像双模态影像的方法合理可行,提高了融合影像信号的清晰度与信噪比。

In order to improve the coupling image quality between optical molecular image and computed tomography (CT) image, the free-form surface optical channels of tumor lesion tissue in optical molecular image and CT image are established based on free-form surface optical technology, and dual-mode image fusion display is realized. The design method of microscopic, multi-spatial and multi-focal free-form surface optical lens and imaging surface of tumor lesion tissue is used. The differential equation of fused lens and imaging surface of dual-mode image is established. The light focal change curve of optical surface of the free-form surface in lesion tissue is solved. The optical channel surfaces of lesion tissue free-form surface are discreted and reconstructed by optical reconstruction technique of free-form surface in reverse engineering, which improves the dual-mode image fusion quality of the optical molecular image and CT image. It is reasonable and feasible to use free surface optical channel technology to fuse dual-mode image of the optical molecular image and CT image, which improves the sharpness and signal-to-noise ratio of fusion image signal.