细胞激光器是激光光子学和生命科学交叉领域的前沿研究方向,其工作原理是,在流体环境中,将荧光蛋白、生物兼容的荧光染料及荧光素等和细胞有机结合在一起,在谐振腔光反馈作用下使弱信号得到振荡放大实现细胞的激光输出。详细阐述了基于法布里-珀罗腔和回音壁模式微腔的细胞激光器的研究现状和基本原理,由于谐振腔对光信号的反馈放大作用,与传统的荧光信号相比,激光信号能够有效增强传感探测的灵敏度,提高分辨率。通过分析细胞等生物组织中发射激光的光谱和模式等信息来研究细胞内部的生理变化过程,为医学治疗诊断、生物材料三维超分辨成像及可集成光源研究等提供新的技术和设计思路。

Cell lasers is a frontier interdisciplinary research field of laser photonics and life sciences, the principle of which is that, under the optical feedback of the cavity, the weak signal can be oscillated and amplified via the combination of fluorescent protein, bio-compatible fluorescent dye and luciferin into cells in the fluidic environment. We present a detailed discussion about the research status and basic principles of Fabry-Perot cavity and whispering-gallery-mode microcavity. Laser-based detection can effectively enhance the sensitivity and resolution compared with the tradition fluorescence-based detection, benefitting from the feedback amplification of cavity. The physiological changes inside cells are studied with the analysis of the spectra and modes of the cell laser emission simultaneously. It'll provide new technologies and design ideas for medical diagnosis, three-dimensional super-resolution imaging of biomaterials and integrated light source research.