中国激光, 2020, 47 (2): 0207032, 网络出版: 2020-02-21
基于多角度光声介观成像方法的小动物肿瘤特异性成像 下载: 1108次特邀研究论文
Tumor-Specific Imaging of Small Animals Based on Multi-Angle Optoacoustic Mesoscopy Imaging Method
医用光学 光声介观 双波长 聚焦超声探测器 多角度扫描 肿瘤实验 medical optics optoacoustic mesoscopy dual-wavelength focused ultrasonic detector multi-angle scanning tumor experiment
摘要
搭建了一套多角度扫描的高灵敏度光声介观(OPAM)实验系统,可同时实现高灵敏度测量和多角度信息获取,并利用该系统对小动物肿瘤的结构信息与功能信息进行了初探。通过仿体实验验证了所搭建系统的空间分辨能力,满足OPAM成像需求;通过对两种小动物肿瘤模型进行OPAM实验,可获得肿瘤的结构图像以及两种肿瘤较为明显的类型特征;之后利用该系统在双波长测量条件下获得了肿瘤的血氧饱和度值。实验表明,该OPAM系统可以为肿瘤学研究提供一定的参考与指导,在生物医学研究领域具有较好的应用前景。
Abstract
In this study, we construct a high-sensitivity optoacoustic mesoscopy (OPAM) experimental system with a multi-angle scanning mode that can simultaneously perform high-sensitivity measurements and achieve multi-angle information acquisition. This system is employed to acquire the structural and functional information related to small-animal tumor models. The spatial resolution of this OPAM experimental system is verified via a phantom experiment that satisfies the OPAM imaging requirements. Further, by applying the OPAM experimental system on two types of small-animal tumor models, their structural images and obvious type characteristics are presented. Subsequently, the blood oxygen saturation values of the tumors are obtained using the OPAM experimental system under the dual-wavelength measurement condition. The experimental results denote that the OPAM experimental system can provide valuable reference and guidance for oncology research and that the proposed system exhibits considerable application prospects in the field of biomedical research.
路彤, 高峰, 宋少泽, 陈婷婷, 苗士超, 李娇. 基于多角度光声介观成像方法的小动物肿瘤特异性成像[J]. 中国激光, 2020, 47(2): 0207032. Lu Tong, Gao Feng, Song Shaoze, Chen Tingting, Miao Shichao, Li Jiao. Tumor-Specific Imaging of Small Animals Based on Multi-Angle Optoacoustic Mesoscopy Imaging Method[J]. Chinese Journal of Lasers, 2020, 47(2): 0207032.