稀土掺杂的上转换纳米发光材料(UCNP)可以将低频光子转化为高频光子,通常是近红外光激发,可见光发射,这个独特的光学性质使其具有良好的生物学应用前景。近年来,UCNP已经在成像、传感等领域取得了重要进展,本文对近年来UCNP的合成、表面修饰以及在生物检测等方面的应用进行综述,涵盖了生物检测方面的重要进展,包括基于上转换荧光的温度、离子、小分子以及生物体内的重要蛋白与核酸等检测应用。

Rare earth doped upconversion nanoluminescent materials (UCNP) can convert low-frequency photons into high-frequency photons, usually near-infrared light excitation and visible light emission. This unique optical property makes it promising for biological applications. In recent years, UCNPs have made significant progress in the imaging and sensing fields. This paper reviews the important progress in synthesis, surface modification, and bioassay using UCNPs, covering important advances in biological detection, and including upconversion fluorescence-based temperature, ions, small molecules, and important proteins and nucleic acids.