中国激光, 2020, 47 (2): 0207034, 网络出版: 2020-02-21
光学相干断层成像术评估细菌诱导性炎症 下载: 914次特邀研究论文
Assessment of Bacterial Inflammation Based on Optical Coherence Tomography Angiography
医用光学 光学相干断层血管造影术 细菌 炎症 血管网络 medical optics optical coherence tomography angiography bacteria inflammation vascular network
摘要
光学相干断层血管造影术(OCTA)是研究微血管网络和微循环的重要工具。采用高灵敏度和高分辨率的光学相干断层血管成像技术对细菌诱导的裸鼠耳朵炎症模型进行监测和评估。成像结果表明:光学相干断层血管造影术可以高灵敏度和高分辨率地监测细菌诱导性炎症过程中,小鼠耳朵免疫血管反应诱发的微血管网络密度差异和血管形态变化;细菌感染之后,小鼠耳朵的OCT(optical coherence tomography)血管信号明显增强,这是由于细菌诱导的血管发炎促进了血管中红细胞的增多,从而增强了OCT信号。最后,健康被试者手掌处的高密集血管网络图像,证明了光学相干断层血管造影术用于临床评估炎症的可能性。该方法有助于进一步认识炎症的病理机制,为临床评估炎症开辟了新途径。
Abstract
Optical coherence tomography angiography (OCTA) is an important tool for investigating microvascular networks and microcirculation in living tissue. In this study, OCTA was employed for noninvasive in vivo monitoring and assessment of inflammation induced by bacteria in a mouse ear model. Imaging results demonstrated that OCTA can monitor changes in microvascular density and morphology of blood vessels caused by immunovascular responses during the inflammatory process with a high degree of resolution and sensitivity. Distinctly enhanced OCT signals from the mouse ear were observed following bacterial infection owing to an influx of red blood cells caused by the bacteria. A highly dense microvascular network noted in the palms of healthy subjects by OCTA, demonstrates the feasibility of OCTA for the clinical evaluation of inflammation. This method can improve the understanding of the pathological mechanisms of inflammation and can be useful in the clinical evaluation of inflammation.
刘玉滨, 陈智毅, 袁振. 光学相干断层成像术评估细菌诱导性炎症[J]. 中国激光, 2020, 47(2): 0207034. Liu Yubin, Chen Zhiyi, Yuan Zhen. Assessment of Bacterial Inflammation Based on Optical Coherence Tomography Angiography[J]. Chinese Journal of Lasers, 2020, 47(2): 0207034.