中国激光, 2004, 31 (3): 381, 网络出版: 2006-06-12   

He-Ne激光与丹参注射液联用对牛中性粒细胞呼吸爆发的影响

Effects of He-Ne Laser Irradiation Combined with Salvia Miltiorrhiza Injection on the Respiratory Burst of Bovine Neutrophils
作者单位
1 华南师范大学信息光电子科技学院,广东 广州 510631
2 暨南大学中医系,广东 广州 510632
3 华南师范大学激光运动医学实验室,广东 广州 510631
摘要
临床上低强度He-Ne激光与丹参注射液配合使用治疗缺血、缺氧性心血管疾病取得良好疗效,但其机理未明.采用化学发光法研究低强度He-Ne激光与丹参注射液联合作用对中性粒细胞(PMN)呼吸爆发的影响,以进一步探讨低强度He-Ne激光与丹参注射液配合使用产生抗缺血、缺氧性损伤效应的机制.实验结果表明低强度He-Ne激光具有对受激PMN呼吸爆发的双向调节作用.200 J/m2,2000 J/m2和3000 J/m2的He-Ne激光能刺激PMN产生呼吸爆发,40 J/m2,1000 J/m2和6000 J/m2的He-Ne激光能抑制PMN 产生呼吸爆发.4~16 μL的丹参注射液能抑制受激PMN的呼吸爆发,且呈一定的量效关系.8 μL的丹参注射液与1000 J/m2的He-Ne激光联合作用能对受激PMN的呼吸爆发产生抑制效应,并且有协同作用.
Abstract
He-Ne laser irradiation combined with salvia miltiorrhiza injection (SM) can treat ischemia and anoxemia well in clinic, but the mechanism remains obscure. In this paper, the effects of low intensity He-Ne laser irradiation, SM, and the combination of He-Ne laser irradiation and SM on the respiratory burst of bovine neutrophils were studied, respectively, which may help to understand the mechanism of the combination of He-Ne laser irradiation and SM fight against ischemic injury. The chemiluminescence was used to measure the respiratory burst of neutrophils. The results showed that 200 J/m2, 2000 J/m2 He-Ne laser irradiation can stimulate the respiratory burst of neutrophils, 40 J/2, 1000 J/m2, 6000 J/m2 He-Ne laser irradiation can inhibit the respiratory burst of neutrophils, 4~16 μL SM can inhibit the respiratory burst of neutrophils, and have the dose-effect relation. The inhibitory effect of the combination of 1000 J/m3 He-Ne laser irradiation and 8 μL SM is more marked than that of only laser or SM.

李艳玲, 角建瓴, 刘承宜, 刘颂豪. He-Ne激光与丹参注射液联用对牛中性粒细胞呼吸爆发的影响[J]. 中国激光, 2004, 31(3): 381. 李艳玲, 角建瓴, 刘承宜, 刘颂豪. Effects of He-Ne Laser Irradiation Combined with Salvia Miltiorrhiza Injection on the Respiratory Burst of Bovine Neutrophils[J]. Chinese Journal of Lasers, 2004, 31(3): 381.

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